Empirical/pre-emptive therapy: Agents of choice.
| . | . | Beneficial effect: Rate (interval), P value . | |
|---|---|---|---|
| Study . | Agents and Population . | Fungal Infections . | Mortality . |
| Abbreviations: LAMB, liposomal amphotericin B; AmB-D, amphotericin B; pts, patients; ABCD, amphotericin B colloidal dispersion; NS, not significant. | |||
| Bow, 200035 | Empirical, Drug vs AmB-D: 2756 cancer patients | ||
| Azoles vs. AmB-D | 1.15 (0.76–1.74) NS | 1.18 (0.47–2.99) NS | |
| LAMB vs. AmB-D | 1.11 (0.7–1.75) NS | 0.35 (0.14–0.87) LAMB ↓ | |
| Johansen, 200236 | Empirical, Polyenes: 1790 cancer patients | ||
| LAMB vs. AmB-D 1149 pts | 0.63 (0.39–1.01) P = .053 LAMB ↓ IFI | 0.74 (0.52–1.07), P = .11 Trend to ↓ with LAMB | |
| Intralipid AmB vs. AmB-D 379 pts | 0.67 (0.12–3.75) NS 0.53 (0.2–1.4), NS | ||
| ABCD vs. AmB-D 262 pts | 1.21 (0.28–5.16) NS | 1.19 (0.61–2.34), NS | |
| Gotzsche, 200233 | Prophylaxis/empirical therapy: Drug more effective than none = 4094 patients | ||
| AmB-D, LAMB | 0.39 (0.2–0.76), P = .01 | 0.73 (0.5–1.03), P = .08 | |
| Itraconazole | 0.51 (0.27–0.96), P = .04 | 0.88 (0.58–1.34), P = .6 | |
| . | . | Beneficial effect: Rate (interval), P value . | |
|---|---|---|---|
| Study . | Agents and Population . | Fungal Infections . | Mortality . |
| Abbreviations: LAMB, liposomal amphotericin B; AmB-D, amphotericin B; pts, patients; ABCD, amphotericin B colloidal dispersion; NS, not significant. | |||
| Bow, 200035 | Empirical, Drug vs AmB-D: 2756 cancer patients | ||
| Azoles vs. AmB-D | 1.15 (0.76–1.74) NS | 1.18 (0.47–2.99) NS | |
| LAMB vs. AmB-D | 1.11 (0.7–1.75) NS | 0.35 (0.14–0.87) LAMB ↓ | |
| Johansen, 200236 | Empirical, Polyenes: 1790 cancer patients | ||
| LAMB vs. AmB-D 1149 pts | 0.63 (0.39–1.01) P = .053 LAMB ↓ IFI | 0.74 (0.52–1.07), P = .11 Trend to ↓ with LAMB | |
| Intralipid AmB vs. AmB-D 379 pts | 0.67 (0.12–3.75) NS 0.53 (0.2–1.4), NS | ||
| ABCD vs. AmB-D 262 pts | 1.21 (0.28–5.16) NS | 1.19 (0.61–2.34), NS | |
| Gotzsche, 200233 | Prophylaxis/empirical therapy: Drug more effective than none = 4094 patients | ||
| AmB-D, LAMB | 0.39 (0.2–0.76), P = .01 | 0.73 (0.5–1.03), P = .08 | |
| Itraconazole | 0.51 (0.27–0.96), P = .04 | 0.88 (0.58–1.34), P = .6 | |