Toxicity
| Symptoms . | IFN + PUVA . | IFN + Acitretin . | ||||
|---|---|---|---|---|---|---|
| WHO Grade . | WHO Grade . | |||||
| I . | II . | III . | I . | II . | III . | |
| Flu-like symptoms | 10 | 10 | 1 | 9 | 13 | 7 |
| Dryness/redness of the skin and/or hair loss | 3 | 5 | 1 | 4 | 8 | 2 |
| Neurological disorders | 2 | 1 | 0 | 6 | 2 | 3 |
| Psychiatric disorders | 0 | 2 | 0 | 0 | 2 | 1 |
| Gastrointestinal disorders | 7 | 3 | 0 | 4 | 3 | 1 |
| Elevated liver or biliary tract enzymes | 1 | 1 | 0 | 3 | 1 | 1 |
| Elevated triglycerides | 0 | 0 | 0 | 2 | 1 | 2 |
| Anemia | 2 | 0 | 0 | 0 | 2 | 0 |
| Leukopenia | 6 | 2 | 1 | 7 | 2 | 0 |
| Impotentia | 1 | 1 | 0 | 0 | 0 | 1 |
| Redness and infiltration at application site | 1 | 0 | 2 | 0 | 0 | 0 |
| Symptoms . | IFN + PUVA . | IFN + Acitretin . | ||||
|---|---|---|---|---|---|---|
| WHO Grade . | WHO Grade . | |||||
| I . | II . | III . | I . | II . | III . | |
| Flu-like symptoms | 10 | 10 | 1 | 9 | 13 | 7 |
| Dryness/redness of the skin and/or hair loss | 3 | 5 | 1 | 4 | 8 | 2 |
| Neurological disorders | 2 | 1 | 0 | 6 | 2 | 3 |
| Psychiatric disorders | 0 | 2 | 0 | 0 | 2 | 1 |
| Gastrointestinal disorders | 7 | 3 | 0 | 4 | 3 | 1 |
| Elevated liver or biliary tract enzymes | 1 | 1 | 0 | 3 | 1 | 1 |
| Elevated triglycerides | 0 | 0 | 0 | 2 | 1 | 2 |
| Anemia | 2 | 0 | 0 | 0 | 2 | 0 |
| Leukopenia | 6 | 2 | 1 | 7 | 2 | 0 |
| Impotentia | 1 | 1 | 0 | 0 | 0 | 1 |
| Redness and infiltration at application site | 1 | 0 | 2 | 0 | 0 | 0 |
Some patients with more than one adverse event are shown.