Clinical Details
| Patient No. . | Age/Sex . | Relevant Clinical Data . | Clinical Outcome . |
|---|---|---|---|
| Complicated CD | |||
| 1 | 49/M | Adult-onset CD unresponsive to GFD. | Liver TCL 12 mo after diagnosis of CD. Died 6 mo later. |
| 2 | 44/F | Diarrhea since childhood, ulcerative jejunitis. | Liver TCL 4 mo after diagnosis of CD. Died in remission 10 mo later. |
| 3 | 68/F | Adult-onset CD unresponsive to GFD, cavitation of mesenteric lymph nodes, pancreatic cysts, bronchectasia, autoimmune hypothyroidism. | Symptomatic remission with low-dose steroids for 11 yrs. Ulcerations of the colon (small lymphocyte infiltration). Died of pulmonary embolism. |
| 4 | 46/F | Adult-onset CD. GFD not followed for 2 yrs, subsequently unresponsive to GFD, ulcerative duodenitis. | Hemophagocytic syndrome and large-cell lymphoma of the bone marrow diagnosed 31 mo after CD. Died soon thereafter. |
| Untreated CD responsive to GFD | |||
| 5 | 33/M | Adult-onset CD. | Clinical and biological remission under GFD/39 mo of follow-up. |
| 6 | 73/M | Adult-onset CD. | Clinical and biological remission under GFD/43 mo of follow-up. |
| 7 | 24/M | Relapse of childhood-onset CD. | Clinical and biological remission under GFD/49 mo of follow-up. |
| 8 | 18/F | Relapse of childhood-onset CD. | Clinical, biological, and histological remission under GFD/26 mo of follow-up. |
| 9 | 25/F | Childhood-onset CD. | Clinical and biological remission under GFD/30 mo of follow-up. |
| 10 | 38/R | Adult-onset CD. | Clinical, biological, and histological remission under GFD/49 mo of follow-up. |
| 11 | 23/F | Adult-onset CD. | Clinical, biological, and histological remission under GFD/48 mo of follow-up. |
| Controls | |||
| 12 | 24/M | Nonulcer dyspepsia. | |
| 13 | 52/F | Nonulcer dyspepsia. | |
| 14 | 43/M | Nonulcer dyspepsia. | |
| 15 | 27/M | Nonulcer dyspepsia. |
| Patient No. . | Age/Sex . | Relevant Clinical Data . | Clinical Outcome . |
|---|---|---|---|
| Complicated CD | |||
| 1 | 49/M | Adult-onset CD unresponsive to GFD. | Liver TCL 12 mo after diagnosis of CD. Died 6 mo later. |
| 2 | 44/F | Diarrhea since childhood, ulcerative jejunitis. | Liver TCL 4 mo after diagnosis of CD. Died in remission 10 mo later. |
| 3 | 68/F | Adult-onset CD unresponsive to GFD, cavitation of mesenteric lymph nodes, pancreatic cysts, bronchectasia, autoimmune hypothyroidism. | Symptomatic remission with low-dose steroids for 11 yrs. Ulcerations of the colon (small lymphocyte infiltration). Died of pulmonary embolism. |
| 4 | 46/F | Adult-onset CD. GFD not followed for 2 yrs, subsequently unresponsive to GFD, ulcerative duodenitis. | Hemophagocytic syndrome and large-cell lymphoma of the bone marrow diagnosed 31 mo after CD. Died soon thereafter. |
| Untreated CD responsive to GFD | |||
| 5 | 33/M | Adult-onset CD. | Clinical and biological remission under GFD/39 mo of follow-up. |
| 6 | 73/M | Adult-onset CD. | Clinical and biological remission under GFD/43 mo of follow-up. |
| 7 | 24/M | Relapse of childhood-onset CD. | Clinical and biological remission under GFD/49 mo of follow-up. |
| 8 | 18/F | Relapse of childhood-onset CD. | Clinical, biological, and histological remission under GFD/26 mo of follow-up. |
| 9 | 25/F | Childhood-onset CD. | Clinical and biological remission under GFD/30 mo of follow-up. |
| 10 | 38/R | Adult-onset CD. | Clinical, biological, and histological remission under GFD/49 mo of follow-up. |
| 11 | 23/F | Adult-onset CD. | Clinical, biological, and histological remission under GFD/48 mo of follow-up. |
| Controls | |||
| 12 | 24/M | Nonulcer dyspepsia. | |
| 13 | 52/F | Nonulcer dyspepsia. | |
| 14 | 43/M | Nonulcer dyspepsia. | |
| 15 | 27/M | Nonulcer dyspepsia. |
Abbreviation: TCL, T-cell lymphoma; CD, celiac disease; GFD, gluten-free diet.