Table 2. Patient Characteristics and... | American Society of Hematology

Table 2.

Patient Characteristics and Cytokine Genotypes With the Development of GVHD Grades III-IV

UPN	Diagnosis	CR	HLA Type	TNF − 308	IL-10 Genotype	TNFd Genotype	GVHD Occurrence	Survival Posttransplant (mo)	Cause of Death
39	CGL	Cy/TBI	A2 A9 (24) B7 Bw22 (55) Cw3	F1/F1	i13/13^*	d3/d3^†	III	152
40	AML	M/TBI	A2 A30 (19) B13 B39 (16) DR17 DR8	F1/F1	i9/13^*	d3/d3^†	III	25
41	ALL	M/TBI	A28 A30 (19) B27 B44 (12) DR1501-1503 DR0701	F1/F1	i11/13^*	d3/d3^†	III	12
42	CGL	Bu/M	A1 A11 B5 B57 (17) DR4 DR71 (3)	F1/F1	i12/12^*	d4/d4	III	2	Fungal infection
43	AML	M/TBI	A25 A31 B18 B40 DR2 DR4	F1/F1	i8/15^*	d3/d3^†	III	1	Allotoxicity
44	CGL	Cy/TBI	A2 A3 B8 B5 DR3 DR5	F1/F2	i8/13^*	d1/d3	III	2	GVHD and viral infection
45	AML	M/TBI	A2 A3 B7 DR2 DR4	F1/F1	9/14^*	d3/d3^†	III	59
46	ALL	Cy/TBI	A1 A3 B17 B15 DR4 DR7	F1/F1	i9/9	d4/d4	III	107
47	AML	M/TBI	A1 A3 B8 B35 DR1 DR17 (3)	F1/F2	i9/13^*	d1/d4	III	122	Nontransplant?? related death
48	MDS	Bu/Cy	A11 A32 B7 B4 DR4 DR7	F1/F1	i9/9	d3/d3^†	IV	2	GVHD
49	AML	M/TBI	A2 A29 (19) B44 (12) DR4 DR7	F1/F1	i10/13^*	d3/d3^†	IV	2	VOD

UPN	Diagnosis	CR	HLA Type	TNF − 308	IL-10 Genotype	TNFd Genotype	GVHD Occurrence	Survival Posttransplant (mo)	Cause of Death
39	CGL	Cy/TBI	A2 A9 (24) B7 Bw22 (55) Cw3	F1/F1	i13/13^*	d3/d3^†	III	152
40	AML	M/TBI	A2 A30 (19) B13 B39 (16) DR17 DR8	F1/F1	i9/13^*	d3/d3^†	III	25
41	ALL	M/TBI	A28 A30 (19) B27 B44 (12) DR1501-1503 DR0701	F1/F1	i11/13^*	d3/d3^†	III	12
42	CGL	Bu/M	A1 A11 B5 B57 (17) DR4 DR71 (3)	F1/F1	i12/12^*	d4/d4	III	2	Fungal infection
43	AML	M/TBI	A25 A31 B18 B40 DR2 DR4	F1/F1	i8/15^*	d3/d3^†	III	1	Allotoxicity
44	CGL	Cy/TBI	A2 A3 B8 B5 DR3 DR5	F1/F2	i8/13^*	d1/d3	III	2	GVHD and viral infection
45	AML	M/TBI	A2 A3 B7 DR2 DR4	F1/F1	9/14^*	d3/d3^†	III	59
46	ALL	Cy/TBI	A1 A3 B17 B15 DR4 DR7	F1/F1	i9/9	d4/d4	III	107
47	AML	M/TBI	A1 A3 B8 B35 DR1 DR17 (3)	F1/F2	i9/13^*	d1/d4	III	122	Nontransplant?? related death
48	MDS	Bu/Cy	A11 A32 B7 B4 DR4 DR7	F1/F1	i9/9	d3/d3^†	IV	2	GVHD
49	AML	M/TBI	A2 A29 (19) B44 (12) DR4 DR7	F1/F1	i10/13^*	d3/d3^†	IV	2	VOD

Characteristics and results on patients with grade III-IV GVHD showing unique patient number (UPN), diagnosis, conditioning regimes available HLA typing results, genotype for the TNF ⁻308, IL-10 ⁻¹064, and TNFd microsatellite polymorphisms, occurrence of acute GVHD, survival, and cause of death.

Abbreviations: VOD, veno-occlusive disease; Cy/TBI, cyclophosphamide/TBI; M/TBI, melphalan/TBI. C/Bu, Busulphan; M/VP16/B, melphalan/atoposide/BCNU.

Patients who possessed an IL-10 microsatellite allele with greater numbers of dinucleotide repeats (alleles 12-15).

†

Patients who were homozygous for the TNFd3 allele (d3/d3).

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