V Replacements in the Clonal IgH Rearrangements of a B-Precursor Leukemia From an Eμ-ret Mouse
| V Family . | 3′ V . | N . | D or Unknown . | DJ Overlap . | 5′ J . | J # . | D Family . | P/NP . |
|---|---|---|---|---|---|---|---|---|
| *Q52 | TGTGCC | CCC | CTATGGTAACT | AC | TACTTT | 2 | SP | NP |
| J558 | TGTACAAGA | GACCC | CTATGGTAACT | AC | TACTTT | 2 | SP | NP |
| J558 | TGTACAAGA | GGACCC | CTATGGTAACT | AC | TACTTT | 2 | SP | NP |
| *7183 | TGTGCAAGAC | GCGGAGG | CCTGGT | 3 | ? | NP | ||
| J558 | TGTGCAAGA | TTGCAAGAC | GCGGAGG | CCTGGT | 3 | ? | NP | |
| J558 | TGTGCAAGA | TTGGTTGCAAGAC | GCGGAGG | CCTGGT | 3 | ? | NP | |
| J558 | TGTGCAAG | GGGAGCAAGAC | GCGGAGG | CCTGGT | 3 | ? | NP |
| V Family . | 3′ V . | N . | D or Unknown . | DJ Overlap . | 5′ J . | J # . | D Family . | P/NP . |
|---|---|---|---|---|---|---|---|---|
| *Q52 | TGTGCC | CCC | CTATGGTAACT | AC | TACTTT | 2 | SP | NP |
| J558 | TGTACAAGA | GACCC | CTATGGTAACT | AC | TACTTT | 2 | SP | NP |
| J558 | TGTACAAGA | GGACCC | CTATGGTAACT | AC | TACTTT | 2 | SP | NP |
| *7183 | TGTGCAAGAC | GCGGAGG | CCTGGT | 3 | ? | NP | ||
| J558 | TGTGCAAGA | TTGCAAGAC | GCGGAGG | CCTGGT | 3 | ? | NP | |
| J558 | TGTGCAAGA | TTGGTTGCAAGAC | GCGGAGG | CCTGGT | 3 | ? | NP | |
| J558 | TGTGCAAG | GGGAGCAAGAC | GCGGAGG | CCTGGT | 3 | ? | NP |
s identify the clonal VDJ joinings originally isolated from the leukemia of Eμ-ret mouse 6/26. The retained 3′ V nucleotides in the V replacement events involving the 7183 VDJ joining are underlined. P/NP signifies whether the rearrangements are productive (P) or nonproductive (NP).