Relative risk of transplant-related mortality, relapse, and treatment failure with high versus low cell doses
| Event . | Variable . | RR (95% CI) . | P . |
|---|---|---|---|
| Transplant-related mortality | High vs low cell dose Advanced vs early/int disease | 0.16 (0.02-1.29) 5.97 (1.14-31.31) | .08 .03 |
| Relapse | High vs low cell dose: | ||
| First 9 mos after transplantation | 1.65 (0.69-3.95) | .26 | |
| >9 mos after transplantation | 0.28 (0.12-0.66) | .003 | |
| Advanced vs early/int disease | 6.21 (2.66-14.47) | <.001 | |
| WBC at diagnosis | |||
| >25 vs ≤25 × 109/L | 2.56 (1.39-4.69) | .002 | |
| CyTBI vs BuCY for conditioning | 0.51 (0.28-0.92) | .02 | |
| Treatment failure | High vs low cell dose: | ||
| First 9 mos after transplantation | 1.16 (0.53-2.53) | .71 | |
| >9 mos after transplantation | 0.27 (0.12-0.60) | .001 | |
| Advanced vs early/int disease | 6.14 (2.87-13.12) | <.001 | |
| WBC at diagnosis | |||
| >25 vs ≤25 × 109/L | 2.42 (1.39-4.21) | .002 | |
| CyTBI vs BuCY for conditioning | 0.57 (0.33-0.99) | .05 | |
| Karnofsky score ≥90% vs <90% | 0.49 (0.24-0.99) | .05 |
| Event . | Variable . | RR (95% CI) . | P . |
|---|---|---|---|
| Transplant-related mortality | High vs low cell dose Advanced vs early/int disease | 0.16 (0.02-1.29) 5.97 (1.14-31.31) | .08 .03 |
| Relapse | High vs low cell dose: | ||
| First 9 mos after transplantation | 1.65 (0.69-3.95) | .26 | |
| >9 mos after transplantation | 0.28 (0.12-0.66) | .003 | |
| Advanced vs early/int disease | 6.21 (2.66-14.47) | <.001 | |
| WBC at diagnosis | |||
| >25 vs ≤25 × 109/L | 2.56 (1.39-4.69) | .002 | |
| CyTBI vs BuCY for conditioning | 0.51 (0.28-0.92) | .02 | |
| Treatment failure | High vs low cell dose: | ||
| First 9 mos after transplantation | 1.16 (0.53-2.53) | .71 | |
| >9 mos after transplantation | 0.27 (0.12-0.60) | .001 | |
| Advanced vs early/int disease | 6.14 (2.87-13.12) | <.001 | |
| WBC at diagnosis | |||
| >25 vs ≤25 × 109/L | 2.42 (1.39-4.21) | .002 | |
| CyTBI vs BuCY for conditioning | 0.57 (0.33-0.99) | .05 | |
| Karnofsky score ≥90% vs <90% | 0.49 (0.24-0.99) | .05 |
RR, relative risk; CI, confidence interval; int, intermediate; Cy, cyclophosphamide; TBI, total body irradiation; Bu, busulfan.