Table 5.

Effect of s-LCA on hematologic recovery and clinical outcomes

Clinical outcome s-LCA negative5-150 (N = 15)s-LCA positive5-150 (N = 8) P5-153
Hematologic recovery  
 Variables  
  CD34 dose (×106/kg)  3.0 (2.0-5.5)  3.8 (1.4-13.1) 0.44  
  Prior chemotherapy regimens  1.9 (1-3) 1.9 (1-2)  0.76  
  Prior chemotherapy cycles 8.8 (3-16)  8.2 (2-15)  0.76  
  Days G-CSF 14.2 (11-18)  17.0 (12-30)  0.10  
 Neutrophil recovery  
  Days to ANC  
   >500/μL 10.8 (9-18)  12.0 (10-15)  0.18  
   >1000/μL 12.1 (10-18)  17.8 (10-36)  0.03  
   >1500/μL 12.6 (10-18)  19.8 (12-36)  0.01  
 Platelet recovery  
  Days to PLTS  
   >20 000/μL 24.0 (9-67)  32.0 (15-85)  0.38  
   >50 000/μL 29.3 (14-49)  34.4 (27-43)  0.40  
Clinical outcomes 
 Febrile days  
  Days 2 to 10  4.1 (0-6) 6.3 (5-8)  0.01  
  Start of regimen to day 1 0.2 (0-2)  0.5 (0-4)  0.47  
 Days IV antibiotics 
  Day 2 to neutrophil engraftment5-151 7.3 (0-11) 10.5 (8-13)  0.01  
  Start of regimen to day 1 0.5 (0-3)  1.0 (0-4)  0.40  
 Days amphotericin B 0 (0-0)  1.3 (0-5)  0.02  
 Platelet transfusions  
  Day 2 to platelet engraftment5-152 3.4 (0-10)  7.6 (1-18)  0.05  
  Start of regimen to day +1  0  0  —  
  Days 2 to 10 2.1 (0-5)  2.6 (1-7)  0.46 
Clinical outcome s-LCA negative5-150 (N = 15)s-LCA positive5-150 (N = 8) P5-153
Hematologic recovery  
 Variables  
  CD34 dose (×106/kg)  3.0 (2.0-5.5)  3.8 (1.4-13.1) 0.44  
  Prior chemotherapy regimens  1.9 (1-3) 1.9 (1-2)  0.76  
  Prior chemotherapy cycles 8.8 (3-16)  8.2 (2-15)  0.76  
  Days G-CSF 14.2 (11-18)  17.0 (12-30)  0.10  
 Neutrophil recovery  
  Days to ANC  
   >500/μL 10.8 (9-18)  12.0 (10-15)  0.18  
   >1000/μL 12.1 (10-18)  17.8 (10-36)  0.03  
   >1500/μL 12.6 (10-18)  19.8 (12-36)  0.01  
 Platelet recovery  
  Days to PLTS  
   >20 000/μL 24.0 (9-67)  32.0 (15-85)  0.38  
   >50 000/μL 29.3 (14-49)  34.4 (27-43)  0.40  
Clinical outcomes 
 Febrile days  
  Days 2 to 10  4.1 (0-6) 6.3 (5-8)  0.01  
  Start of regimen to day 1 0.2 (0-2)  0.5 (0-4)  0.47  
 Days IV antibiotics 
  Day 2 to neutrophil engraftment5-151 7.3 (0-11) 10.5 (8-13)  0.01  
  Start of regimen to day 1 0.5 (0-3)  1.0 (0-4)  0.40  
 Days amphotericin B 0 (0-0)  1.3 (0-5)  0.02  
 Platelet transfusions  
  Day 2 to platelet engraftment5-152 3.4 (0-10)  7.6 (1-18)  0.05  
  Start of regimen to day +1  0  0  —  
  Days 2 to 10 2.1 (0-5)  2.6 (1-7)  0.46 
F5-150

Mean (range).

F5-151

Defined as first day to achieve ANC >500/μL × 3 days.

F5-152

Defined as first day to achieve platelet count >20 000/μL × 7 days, without transfusions.

F5-153

t-test.

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