Human DLBCL-related somatic variants detected in mouse MYD88L265P DLBCLs
| Gene . | Mouse . | Human . | Notes . | ||||
|---|---|---|---|---|---|---|---|
| Residue* . | Domain . | Downstream residue† . | Upstream residue† . | Domain . | aSHM‡ . | Mouse . | |
| Bclaf1 | Q18E | — | — | — | — | — | #2 |
| Dusp2 | L89V (L85) | Rhodanese | V66I | A96V/T | Rhodanese | Known | #2 |
| L67F | A99V/T/fs | ||||||
| L76P | E100D | ||||||
| E84D | L101P/F | ||||||
| P103L | |||||||
| Gna13 | R166Q | G-α | L152F | E167D | G-α | — | #1 |
| R166X | Q169H/X | ||||||
| V174E | |||||||
| F177S | |||||||
| L181X | |||||||
| Klf2 | G35D (G36) | — | E31D | N42D | — | Predicted | #3 |
| P32L/S | S43N | ||||||
| G36D | |||||||
| Malt1 | Q762X (Q754) | — | P768fs | R191X | — | — | #1 |
| Pdgfrb | V567A (V568) | Cytoplasmic | — | — | — | — | #2 |
| Pik3c2a | K391T (K390) | — | — | — | — | — | #2 |
| Pim1 | G28D | — | T23I | K29N | — | Known | #2 |
| K24N | E30K/D/Q/fs | ||||||
| L25V/M | K31R | ||||||
| A26P/T | E32K/Q/fs | ||||||
| P27S | P33S/T | ||||||
| G28D/A/D | |||||||
| Y198F | Kinase | L192V | D200N/H | Kinase | #3 | ||
| L193F/V | G203E/R | ||||||
| K194N | V206M/fs | ||||||
| T196I/S | Y207F | ||||||
| V197I | S208G/R/T | ||||||
| Gene . | Mouse . | Human . | Notes . | ||||
|---|---|---|---|---|---|---|---|
| Residue* . | Domain . | Downstream residue† . | Upstream residue† . | Domain . | aSHM‡ . | Mouse . | |
| Bclaf1 | Q18E | — | — | — | — | — | #2 |
| Dusp2 | L89V (L85) | Rhodanese | V66I | A96V/T | Rhodanese | Known | #2 |
| L67F | A99V/T/fs | ||||||
| L76P | E100D | ||||||
| E84D | L101P/F | ||||||
| P103L | |||||||
| Gna13 | R166Q | G-α | L152F | E167D | G-α | — | #1 |
| R166X | Q169H/X | ||||||
| V174E | |||||||
| F177S | |||||||
| L181X | |||||||
| Klf2 | G35D (G36) | — | E31D | N42D | — | Predicted | #3 |
| P32L/S | S43N | ||||||
| G36D | |||||||
| Malt1 | Q762X (Q754) | — | P768fs | R191X | — | — | #1 |
| Pdgfrb | V567A (V568) | Cytoplasmic | — | — | — | — | #2 |
| Pik3c2a | K391T (K390) | — | — | — | — | — | #2 |
| Pim1 | G28D | — | T23I | K29N | — | Known | #2 |
| K24N | E30K/D/Q/fs | ||||||
| L25V/M | K31R | ||||||
| A26P/T | E32K/Q/fs | ||||||
| P27S | P33S/T | ||||||
| G28D/A/D | |||||||
| Y198F | Kinase | L192V | D200N/H | Kinase | #3 | ||
| L193F/V | G203E/R | ||||||
| K194N | V206M/fs | ||||||
| T196I/S | Y207F | ||||||
| V197I | S208G/R/T | ||||||
Human homolog residues are shown in parenthesis in case of heterogeneity.
Up to 5 missense or truncating mutations 20 amino acids downstream and upstream of the residue altered in mouse MYD88L265P DLBCLs. For MALT1, functionally related mutations are shown. Bold font indicates corresponding residues altered in mouse MYD88L265P and human DLBCLs or having the same effect in the case of Malt1. Based on Chapuy et al,5 Schmitz et al,6 and Reddy et al.54
Aberrant somatic hypermutation (aSHM), according to Schmitz et al.6