Characteristics of bleeds by location among sickle cell disease patients in California, 1991 to 2014
| Variables . | ICH . | GI . | Menorrhagia . | Epistaxis . | Hemophthalmos . | Gross hematuria . | Other . | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n . | % . | n . | % . | n . | % . | n . | % . | n . | % . | n . | % . | n . | % . | |
| All* | 166 | 2.6 | 669 | 10.4 | 243 | 7.2 | 338 | 5.3 | 80 | 1.2 | 49 | 0.8 | 122 | 1.9 |
| Hospitalization frequency | ||||||||||||||
| Less frequent | 72 | 43.4 | 197 | 29.4 | 82 | 33.7 | 118 | 34.9 | 40 | 50.0 | 16 | 32.7 | 36 | 29.5 |
| Frequent | 94 | 56.6 | 472 | 70.6 | 161 | 66.3 | 220 | 65.1 | 40 | 50.0 | 33 | 67.3 | 86 | 70.5 |
| Bleeding present on admission | ||||||||||||||
| Yes | 112 | 67.5 | 359 | 53.7 | 174 | 71.6 | 122 | 36.1 | 46 | 57.5 | 29 | 59.2 | 67 | 54.9 |
| No | 28 | 16.9 | 73 | 10.9 | 4 | 1.6 | 106 | 31.4 | 2 | 2.5 | 9 | 18.4 | 23 | 18.9 |
| Unknown (prior to 1996) | 23 | 13.9 | 112 | 16.7 | 26 | 10.7 | 29 | 8.6 | 14 | 17.5 | — | — | 16 | 13.1 |
| ED | 3 | 1.8 | 125 | 18.7 | 39 | 16.0 | 81 | 24.0 | 18 | 22.5 | 11 | 22.4 | 16 | 13.1 |
| Bleed admission type | ||||||||||||||
| PDD | 163 | 98.2 | 544 | 81.3 | 204 | 84.0 | 257 | 76.0 | 62 | 77.5 | 38 | 77.6 | 106 | 86.9 |
| ED | 3 | 1.8 | 125 | 18.7 | 39 | 16.0 | 81 | 24.0 | 18 | 22.5 | 11 | 22.4 | 16 | 13.1 |
| Age of first bleed, y | ||||||||||||||
| Mean age (standard deviation) | 35.9 (15.8) | 35.9 (14.9) | 33.8 (9.3) | 29.6 (16.2) | 37.2 (11.0) | 26.8 (13.1) | 32.2 (13.1) | |||||||
| Median age (25th, 75th percentiles) | 37 (23, 48) | 35 (24, 47) | 35 (26, 41) | 27 (17, 42) | 38 (30.5, 45.5) | 24 (19, 34) | 31 (23, 39) | |||||||
| Variables . | ICH . | GI . | Menorrhagia . | Epistaxis . | Hemophthalmos . | Gross hematuria . | Other . | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n . | % . | n . | % . | n . | % . | n . | % . | n . | % . | n . | % . | n . | % . | |
| All* | 166 | 2.6 | 669 | 10.4 | 243 | 7.2 | 338 | 5.3 | 80 | 1.2 | 49 | 0.8 | 122 | 1.9 |
| Hospitalization frequency | ||||||||||||||
| Less frequent | 72 | 43.4 | 197 | 29.4 | 82 | 33.7 | 118 | 34.9 | 40 | 50.0 | 16 | 32.7 | 36 | 29.5 |
| Frequent | 94 | 56.6 | 472 | 70.6 | 161 | 66.3 | 220 | 65.1 | 40 | 50.0 | 33 | 67.3 | 86 | 70.5 |
| Bleeding present on admission | ||||||||||||||
| Yes | 112 | 67.5 | 359 | 53.7 | 174 | 71.6 | 122 | 36.1 | 46 | 57.5 | 29 | 59.2 | 67 | 54.9 |
| No | 28 | 16.9 | 73 | 10.9 | 4 | 1.6 | 106 | 31.4 | 2 | 2.5 | 9 | 18.4 | 23 | 18.9 |
| Unknown (prior to 1996) | 23 | 13.9 | 112 | 16.7 | 26 | 10.7 | 29 | 8.6 | 14 | 17.5 | — | — | 16 | 13.1 |
| ED | 3 | 1.8 | 125 | 18.7 | 39 | 16.0 | 81 | 24.0 | 18 | 22.5 | 11 | 22.4 | 16 | 13.1 |
| Bleed admission type | ||||||||||||||
| PDD | 163 | 98.2 | 544 | 81.3 | 204 | 84.0 | 257 | 76.0 | 62 | 77.5 | 38 | 77.6 | 106 | 86.9 |
| ED | 3 | 1.8 | 125 | 18.7 | 39 | 16.0 | 81 | 24.0 | 18 | 22.5 | 11 | 22.4 | 16 | 13.1 |
| Age of first bleed, y | ||||||||||||||
| Mean age (standard deviation) | 35.9 (15.8) | 35.9 (14.9) | 33.8 (9.3) | 29.6 (16.2) | 37.2 (11.0) | 26.8 (13.1) | 32.2 (13.1) | |||||||
| Median age (25th, 75th percentiles) | 37 (23, 48) | 35 (24, 47) | 35 (26, 41) | 27 (17, 42) | 38 (30.5, 45.5) | 24 (19, 34) | 31 (23, 39) | |||||||
First of each bleeding type by location; patients can have multiple bleeds.
Percentage of all patients with SCD.