Comparison of 2 knee replacements: 1 before and 1 after the initiation of emicizumab in a person with hemophilia and an inhibitor
| Surgery . | Knee reimplantation . | |
|---|---|---|
| Left, in 2012 . | Right, in 2018 . | |
| Emicizumab prophylaxis treatment | No | Yes |
| Total preoperative rFVIIa, μg/kg | 120 | 90 |
| Total intraoperative rFVIIa, μg/kg | 555 | 270 |
| Intraoperative blood loss, mL | 1 480 | 500 |
| Total postoperative rFVIIa, μg/kg | 18 120 | 9 810 |
| Total perioperative rFVIIa requirement, μg/kg | ∼18 795 | ∼10 170 |
| Estimated total cost of rFVIIa,* $ | 3 943 566 | 2 133 869 |
| Postoperative RBC transfusions needed, U | 3 | 1 |
| Surgery . | Knee reimplantation . | |
|---|---|---|
| Left, in 2012 . | Right, in 2018 . | |
| Emicizumab prophylaxis treatment | No | Yes |
| Total preoperative rFVIIa, μg/kg | 120 | 90 |
| Total intraoperative rFVIIa, μg/kg | 555 | 270 |
| Intraoperative blood loss, mL | 1 480 | 500 |
| Total postoperative rFVIIa, μg/kg | 18 120 | 9 810 |
| Total perioperative rFVIIa requirement, μg/kg | ∼18 795 | ∼10 170 |
| Estimated total cost of rFVIIa,* $ | 3 943 566 | 2 133 869 |
| Postoperative RBC transfusions needed, U | 3 | 1 |
Based on current average wholesale price (in US dollars) of $2.69 per microgram and current body weight.