Univariable and multivariable analysis for EFS of 455 patients with BCP-ALL relapse by the Cox proportional hazards model
| Variable . | EFS . | |||||||
|---|---|---|---|---|---|---|---|---|
| Univariable . | Multivariable . | |||||||
| n . | HR . | 95% CI . | P . | n . | HR . | 95% CI . | P . | |
| Sex | .754 | |||||||
| Female | 186 | 1 (ref) | ||||||
| Male | 257 | 1.04 | 0.80-1.36 | |||||
| Site of relapse | .232 | <.001 | ||||||
| Isolated bone marrow | 344 | 1 (ref) | 334 | 1 (ref) | ||||
| Combined bone marrow | 106 | 0.82 | .60-1.13 | 97 | 0.55 | 0.39-0.77 | ||
| Time between initial diagnosis and first relapse, y | 443 | 0.71 | 0.65-0.78 | <.001 | 431 | 0.59 | 0.51-0.67 | <.001 |
| HSCT after first relapse (time-dependent covariate) | 443 | 0.49 | 0.39-0.62 | <.001 | 431 | 0.27 | 0.20-0.37 | <.001 |
| NT5C2 | <.001 | |||||||
| Wild-type | 369 | 1 (ref) | 355 | 1 (ref) | ||||
| Clonal mutation | 27 | 2.20 | 1.38-3.50 | 0.001 | 26 | 1.42 | 0.87-2.31 | .165 |
| Subclonal mutation | 47 | 2.82 | 1.97-4.04 | <.001 | 47 | 1.89 | 1.28-2.69 | .001 |
| TP53 | <.001 | <.001 | ||||||
| Wild-type | 378 | 1 (ref) | 378 | 1 (ref) | ||||
| Mutation and/or deletion | 50 | 2.62 | 1.85-3.70 | 50 | 2.19 | 1.54-3.10 | ||
| Variable . | EFS . | |||||||
|---|---|---|---|---|---|---|---|---|
| Univariable . | Multivariable . | |||||||
| n . | HR . | 95% CI . | P . | n . | HR . | 95% CI . | P . | |
| Sex | .754 | |||||||
| Female | 186 | 1 (ref) | ||||||
| Male | 257 | 1.04 | 0.80-1.36 | |||||
| Site of relapse | .232 | <.001 | ||||||
| Isolated bone marrow | 344 | 1 (ref) | 334 | 1 (ref) | ||||
| Combined bone marrow | 106 | 0.82 | .60-1.13 | 97 | 0.55 | 0.39-0.77 | ||
| Time between initial diagnosis and first relapse, y | 443 | 0.71 | 0.65-0.78 | <.001 | 431 | 0.59 | 0.51-0.67 | <.001 |
| HSCT after first relapse (time-dependent covariate) | 443 | 0.49 | 0.39-0.62 | <.001 | 431 | 0.27 | 0.20-0.37 | <.001 |
| NT5C2 | <.001 | |||||||
| Wild-type | 369 | 1 (ref) | 355 | 1 (ref) | ||||
| Clonal mutation | 27 | 2.20 | 1.38-3.50 | 0.001 | 26 | 1.42 | 0.87-2.31 | .165 |
| Subclonal mutation | 47 | 2.82 | 1.97-4.04 | <.001 | 47 | 1.89 | 1.28-2.69 | .001 |
| TP53 | <.001 | <.001 | ||||||
| Wild-type | 378 | 1 (ref) | 378 | 1 (ref) | ||||
| Mutation and/or deletion | 50 | 2.62 | 1.85-3.70 | 50 | 2.19 | 1.54-3.10 | ||
Values of P < .05 are depicted in bold.
Multivariable analysis of NT5C2 included all variables, and variables retained in the final Cox model are shown.
HSCT, hematopoietic stem cell transplantation; ref, reference.