Laboratory data at diagnosis by FLT3-ITD, NPM1, and age (mean with standard deviation), with Kolmogorov-Smirnov 2-sample test for pairwise comparison of genetic subgroups A, B, C, and D
| . | No FLT3-ITD . | FLT3-ITD . | . | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| NPM1-mut . | NPM1 wt . | NPM1-mut . | NPM1 wt . | <60 y . | 60-74 y . | |||||||||||||||
| Group . | A . | B . | C . | D . | A vs B . | A vs C . | A vs D . | B vs C . | B vs D . | C vs D . | A vs B . | A vs C . | A vs D . | B vs C . | B vs D . | C vs D . | ||||
| Age group, y | <60 | 60-74 | <60 | 60-74 | <60 | 60-74 | <60 | 60-74 | ||||||||||||
| Age, y | 48 (10) | 67 (4) | 44 (11) | 67 (4) | 48 (9) | 67 (4) | 42 (13) | 67 (4) | * | * | ** | |||||||||
| Hemoglobin, g/L | 95 (20) | 95 (20) | 95 (23) | 94 (19) | 96 (22) | 98 (22) | 91 (22) | 92 (18) | ||||||||||||
| Platelet count, ×109/L | 109 (86) | 106 (113) | 98 (104) | 100 (103) | 86 (87) | 87 (82) | 71 (73) | 99 (86) | * | *** | **** | |||||||||
| WBC, ×109/L | 33 (47) | 49 (70) | 26 (53) | 19 (39) | 80 (78) | 74 (67) | 71 (79) | 68 (77) | ** | **** | *** | **** | **** | **** | **** | **** | **** | |||
| Blood blast count, ×109/L | 14 (27) | 28 (54) | 17 (45) | 9 (28) | 53 (71) | 48 (57) | 49 (65) | 32 (47) | **** | **** | **** | **** | **** | **** | **** | **** | ||||
| Bone marrow blasts, % | 51 (24) | 56 (25) | 53 (25) | 47 (23) | 66 (23) | 66 (24) | 65 (22) | 57 (22) | *** | *** | **** | **** | *** | * | **** | *** | * | |||
| LDH, ukat/L (normal <4.2) | 8 (5) | 9 (8) | 10 (17) | 8 (12) | 14 (12) | 8 (13) | 13 (9) | 11 (11) | * | **** | *** | **** | **** | *** | **** | * | **** | **** | ||
| . | No FLT3-ITD . | FLT3-ITD . | . | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| NPM1-mut . | NPM1 wt . | NPM1-mut . | NPM1 wt . | <60 y . | 60-74 y . | |||||||||||||||
| Group . | A . | B . | C . | D . | A vs B . | A vs C . | A vs D . | B vs C . | B vs D . | C vs D . | A vs B . | A vs C . | A vs D . | B vs C . | B vs D . | C vs D . | ||||
| Age group, y | <60 | 60-74 | <60 | 60-74 | <60 | 60-74 | <60 | 60-74 | ||||||||||||
| Age, y | 48 (10) | 67 (4) | 44 (11) | 67 (4) | 48 (9) | 67 (4) | 42 (13) | 67 (4) | * | * | ** | |||||||||
| Hemoglobin, g/L | 95 (20) | 95 (20) | 95 (23) | 94 (19) | 96 (22) | 98 (22) | 91 (22) | 92 (18) | ||||||||||||
| Platelet count, ×109/L | 109 (86) | 106 (113) | 98 (104) | 100 (103) | 86 (87) | 87 (82) | 71 (73) | 99 (86) | * | *** | **** | |||||||||
| WBC, ×109/L | 33 (47) | 49 (70) | 26 (53) | 19 (39) | 80 (78) | 74 (67) | 71 (79) | 68 (77) | ** | **** | *** | **** | **** | **** | **** | **** | **** | |||
| Blood blast count, ×109/L | 14 (27) | 28 (54) | 17 (45) | 9 (28) | 53 (71) | 48 (57) | 49 (65) | 32 (47) | **** | **** | **** | **** | **** | **** | **** | **** | ||||
| Bone marrow blasts, % | 51 (24) | 56 (25) | 53 (25) | 47 (23) | 66 (23) | 66 (24) | 65 (22) | 57 (22) | *** | *** | **** | **** | *** | * | **** | *** | * | |||
| LDH, ukat/L (normal <4.2) | 8 (5) | 9 (8) | 10 (17) | 8 (12) | 14 (12) | 8 (13) | 13 (9) | 11 (11) | * | **** | *** | **** | **** | *** | **** | * | **** | **** | ||