Upregulated pathways and transcription factor targets at the time of TA-TMA diagnosis as compared with pretransplant baseline
| Upregulated pathways and TF targets . | Bonferroni adjusted P* . |
|---|---|
| KEGG pathways | |
| Staphylococcus aureus infection | 2.73e-10 |
| Osteoclast differentiation | 1.09e-06 |
| Complement and coagulation cascades | 1.84e-05 |
| TF targets (TFactS database) | |
| STAT1 | .00041 |
| SP1 | .00052 |
| SPI1 | .00112 |
| TF targets (ENCODE) | |
| STAT1 targets K562 interferon-α 30 min | 2.73e-07 |
| STAT1 targets K562 interferon-α 6 h | 6.08e-07 |
| STAT2 targets K562 interferon-α 6 h | 1.31e-06 |
| STAT2 targets K562 interferon-α 30 min | .00027 |
| MSigDb hallmark gene sets | |
| Hallmark interferon-γ response | 2.73e-07 |
| Hallmark inflammatory response | 6.08e-07 |
| Hallmark interferon-α response | 1.31e-06 |
| Hallmark G2M checkpoint | .00027 |
| Upregulated pathways and TF targets . | Bonferroni adjusted P* . |
|---|---|
| KEGG pathways | |
| Staphylococcus aureus infection | 2.73e-10 |
| Osteoclast differentiation | 1.09e-06 |
| Complement and coagulation cascades | 1.84e-05 |
| TF targets (TFactS database) | |
| STAT1 | .00041 |
| SP1 | .00052 |
| SPI1 | .00112 |
| TF targets (ENCODE) | |
| STAT1 targets K562 interferon-α 30 min | 2.73e-07 |
| STAT1 targets K562 interferon-α 6 h | 6.08e-07 |
| STAT2 targets K562 interferon-α 6 h | 1.31e-06 |
| STAT2 targets K562 interferon-α 30 min | .00027 |
| MSigDb hallmark gene sets | |
| Hallmark interferon-γ response | 2.73e-07 |
| Hallmark inflammatory response | 6.08e-07 |
| Hallmark interferon-α response | 1.31e-06 |
| Hallmark G2M checkpoint | .00027 |
TF, transcription factor.
Bonferroni adjusted P < .01.