Table 2. Prognostic scoring systems in... | American Society of Hematology

Table 2.

Prognostic scoring systems in SM

Parameter	REMA (for ISM)		MAPS	IPSM		MARS	GPS
Parameter	OS	PFS	MAPS	Nonadvanced	Advanced	MARS	OS	PFS
WHO (advSM)			+
Age ≥60 y			+	+	+	+
Anemia, g/dL
≤10						+
≤11					+		+
Thrombocytopenia, × 10⁹/L
<100					+	+		+
<150			+
Leukocytosis, × 10⁹/L
≥16					+
Increased serum markers
Baseline serum tryptase					+			+
β2-microglobulin		+						+
Alkaline phosphatase			+	+			+
Genetics
BM KIT D816V VAF ≥1%		+
Additional somatic mutations	+ (A/R/D)	+ (A/R/D)	+ (A/R/NRAS)			+ (S/A/R)	+ (S/A/R/D)

Parameter	REMA (for ISM)		MAPS	IPSM		MARS	GPS
Parameter	OS	PFS	MAPS	Nonadvanced	Advanced	MARS	OS	PFS
WHO (advSM)			+
Age ≥60 y			+	+	+	+
Anemia, g/dL
≤10						+
≤11					+		+
Thrombocytopenia, × 10⁹/L
<100					+	+		+
<150			+
Leukocytosis, × 10⁹/L
≥16					+
Increased serum markers
Baseline serum tryptase					+			+
β2-microglobulin		+						+
Alkaline phosphatase			+	+			+
Genetics
BM KIT D816V VAF ≥1%		+
Additional somatic mutations	+ (A/R/D)	+ (A/R/D)	+ (A/R/NRAS)			+ (S/A/R)	+ (S/A/R/D)

Adapted from Muñoz-González and Orfao⁸⁵ with permission.

A, ASXL1; D, DNMT3A; GPS, global prognostic scoring system; R, RUNX1; S, SRSF2.