Diagnostic criteria for iMCD-TAFRO
| Criteria . |
|---|
| Histopathological criteria: need all |
| Typical LN pathology (atrophic GCs with enlarged nuclei of ECs, proliferation of endothelial venules, small numbers of mature PCs) |
| Negative LANA-1 for HHV8 |
| Major criteria: need 3 of 5 |
| Thrombocytopenia (<100 000/μL) |
| Anasarca (pleural effusions and ascites on CT) |
| Fever (>38°C) |
| Reticulin fibrosis |
| Organomegaly |
| Minor criteria: at least 1 |
| Hyper/normoplasia of megakaryocytes |
| High alkaline phosphatase without markedly elevated transaminases |
| Criteria . |
|---|
| Histopathological criteria: need all |
| Typical LN pathology (atrophic GCs with enlarged nuclei of ECs, proliferation of endothelial venules, small numbers of mature PCs) |
| Negative LANA-1 for HHV8 |
| Major criteria: need 3 of 5 |
| Thrombocytopenia (<100 000/μL) |
| Anasarca (pleural effusions and ascites on CT) |
| Fever (>38°C) |
| Reticulin fibrosis |
| Organomegaly |
| Minor criteria: at least 1 |
| Hyper/normoplasia of megakaryocytes |
| High alkaline phosphatase without markedly elevated transaminases |
Adapted from Iwaki et al10 with permission.
CT, computed tomography scan; EC, endothelial cell; GC, germinal center; LN, lymph node.