Table 1. Summary of Chk, Csk, and Ptprj... | American Society of Hematology

Table 1.

Summary of Chk, Csk, and Ptprj knockout mouse phenotypes

Phenotype	Genotype
Phenotype	Chk KO	Csk KO²	Ptprj KO^2,5	Chk; Csk DKO	Csk; Ptprj DKO²	Chk; Csk; Ptprj TKO
Platelet count	—	↓↓	—	↓↓↓	—	↓
Reticulated platelets	—	↑	—	↑↑↑	↑	↑
MK count in bone marrow	—	↑	—	—	—	↑
MK count in spleen	—	↑↑	↑	↑↑↑	↑↑	↑↑↑
Splenomegaly	—	↑	—	↑↑↑	↑	↑
Myelofibrosis in bone marrow	—	—	—	↑↑	—	↑↑
SFK activity	—	↑	↓↓	—	↑↑	↑
Platelet receptor expression
GPIbα	—	↑↑	—	↑↑	↑	—
GPVI	—	↓↓	↓	↓↓	↓↓	↓↓↓
CLEC-2	—	↓	—	↓	↓↓	↓↓
MPIG6B	↓	↑↑	—	—	↑↑	↑↑
Platelet spreading (fibrinogen)	—	↑	↓	↑	—	—
Bleeding	—	↑	—	↑↑↑	↑↑	—

Phenotype	Genotype
Phenotype	Chk KO	Csk KO²	Ptprj KO^2,5	Chk; Csk DKO	Csk; Ptprj DKO²	Chk; Csk; Ptprj TKO
Platelet count	—	↓↓	—	↓↓↓	—	↓
Reticulated platelets	—	↑	—	↑↑↑	↑	↑
MK count in bone marrow	—	↑	—	—	—	↑
MK count in spleen	—	↑↑	↑	↑↑↑	↑↑	↑↑↑
Splenomegaly	—	↑	—	↑↑↑	↑	↑
Myelofibrosis in bone marrow	—	—	—	↑↑	—	↑↑
SFK activity	—	↑	↓↓	—	↑↑	↑
Platelet receptor expression
GPIbα	—	↑↑	—	↑↑	↑	—
GPVI	—	↓↓	↓	↓↓	↓↓	↓↓↓
CLEC-2	—	↓	—	↓	↓↓	↓↓
MPIG6B	↓	↑↑	—	—	↑↑	↑↑
Platelet spreading (fibrinogen)	—	↑	↓	↑	—	—
Bleeding	—	↑	—	↑↑↑	↑↑	—

↑ upregulated, ↓ downregulated, — normal.