Clinicopathological correlations with eGFR at LCCN diagnosis
| Variable . | Baseline eGFR (mL/min/1.73 m2) . | P . |
|---|---|---|
| Age, y | ||
| ≤60 | 16 ± 15 | .04 (≤60 compared with >60) |
| 60-70 | 12 ± 9 | |
| >70 | 11 ± 9 | |
| LCCN at myeloma relapse | ||
| Absent | 13 ± 12 | .73 |
| Present | 15 ± 9 | |
| Proteinuria, g/d | ||
| ≤2.0 | 12 ± 9 | .03 (>4 g/d compared with ≤4 g/d) |
| 2.1-4.0 | 12 ± 9 | |
| >4.0 | 17 ± 16 | |
| Free light chains, mg/L | ||
| ≤3500 | 15 ± 11 | .04 (trend test) |
| 3501-7000 | 14 ± 14 | |
| >7000 | 11 ± 10 | |
| Lactic acid dehydrogenase, U/L | ||
| ≤200 | 16 ± 15 | .03 (trend test) |
| 201-400 | 12 ± 9 | |
| >400 | 11 ± 9 | |
| β2-microglobulin, mg/L | ||
| ≤10.0 | 22 ± 17 | <.001 (trend test) |
| 10.1-20.0 | 12 ± 8 | |
| >20.0 | 7 ± 6 | |
| Bone marrow plasma cells, % | ||
| ≤33% | 16 ± 11 | .05 |
| 34-66 | 13 ± 14 | |
| >66% | 11 ± 8 | |
| Medulla interstitial inflammation, 0 vs 1-2+ | ||
| 0 | 20 ± 20 | .04 |
| 1 to ≥2 | 12 ± 9 | |
| Giant cell reaction around casts, yes/no | ||
| Absent | 16 ± 15 | .003 |
| Present | 11 ± 7 | |
| Cortex: highest number of casts/mm2 | ||
| ≤5 | 18 ± 17 | <.001 (trend test) |
| 5-10 | 11 ± 7 | |
| >10 | 12 ± 9 | |
| Cortex: mean number of casts/mm2 | ||
| ≤2 | 18 ± 16 | <.001 (trend test) |
| 2-5 | 12 ± 8 | |
| >5 | 11 ± 8 | |
| Medulla: highest number of casts/mm2 | ||
| ≤3 | 20 ± 19 | <.001 (trend test) |
| 3-7 | 12 ± 10 | |
| >7 | 10 ± 9 | |
| Medulla: mean number of casts/mm2 | ||
| ≤1.5 | 19 ± 18 | <.001 (trend test) |
| 1.5-3.0 | 13 ± 11 | |
| >3.0 | 11 ± 9 |
| Variable . | Baseline eGFR (mL/min/1.73 m2) . | P . |
|---|---|---|
| Age, y | ||
| ≤60 | 16 ± 15 | .04 (≤60 compared with >60) |
| 60-70 | 12 ± 9 | |
| >70 | 11 ± 9 | |
| LCCN at myeloma relapse | ||
| Absent | 13 ± 12 | .73 |
| Present | 15 ± 9 | |
| Proteinuria, g/d | ||
| ≤2.0 | 12 ± 9 | .03 (>4 g/d compared with ≤4 g/d) |
| 2.1-4.0 | 12 ± 9 | |
| >4.0 | 17 ± 16 | |
| Free light chains, mg/L | ||
| ≤3500 | 15 ± 11 | .04 (trend test) |
| 3501-7000 | 14 ± 14 | |
| >7000 | 11 ± 10 | |
| Lactic acid dehydrogenase, U/L | ||
| ≤200 | 16 ± 15 | .03 (trend test) |
| 201-400 | 12 ± 9 | |
| >400 | 11 ± 9 | |
| β2-microglobulin, mg/L | ||
| ≤10.0 | 22 ± 17 | <.001 (trend test) |
| 10.1-20.0 | 12 ± 8 | |
| >20.0 | 7 ± 6 | |
| Bone marrow plasma cells, % | ||
| ≤33% | 16 ± 11 | .05 |
| 34-66 | 13 ± 14 | |
| >66% | 11 ± 8 | |
| Medulla interstitial inflammation, 0 vs 1-2+ | ||
| 0 | 20 ± 20 | .04 |
| 1 to ≥2 | 12 ± 9 | |
| Giant cell reaction around casts, yes/no | ||
| Absent | 16 ± 15 | .003 |
| Present | 11 ± 7 | |
| Cortex: highest number of casts/mm2 | ||
| ≤5 | 18 ± 17 | <.001 (trend test) |
| 5-10 | 11 ± 7 | |
| >10 | 12 ± 9 | |
| Cortex: mean number of casts/mm2 | ||
| ≤2 | 18 ± 16 | <.001 (trend test) |
| 2-5 | 12 ± 8 | |
| >5 | 11 ± 8 | |
| Medulla: highest number of casts/mm2 | ||
| ≤3 | 20 ± 19 | <.001 (trend test) |
| 3-7 | 12 ± 10 | |
| >7 | 10 ± 9 | |
| Medulla: mean number of casts/mm2 | ||
| ≤1.5 | 19 ± 18 | <.001 (trend test) |
| 1.5-3.0 | 13 ± 11 | |
| >3.0 | 11 ± 9 |