OS
| Multivariable analysis . | Hazard ratio (95% CI) . | P . |
|---|---|---|
| Excluding mCG (base model) | ||
| R-ISS III vs I | 3.15 (2.11-4.69) | <.001 |
| R-ISS II vs I | 1.57 (1.13-2.18) | .007 |
| Age ≥70 y | 2.20 (1.75-2.78) | <.001 |
| Including mCG | ||
| R-ISS III vs I | 2.83 (1.89-4.23) | <.001 |
| R-ISS II vs I | 1.51 (1.08-2.10) | .015 |
| Age ≥70 y | 2.28 (1.81-2.88) | <.001 |
| Abnormal mCG | 1.61 (1.25-2.07) | <.001 |
| Including del(13q)/monosomy 13 | ||
| R-ISS III vs I | 2.79 (1.86-4.19) | <.001 |
| R-ISS II vs I | 1.51 (1.09-2.11) | .014 |
| Age ≥70 y | 2.29 (1.81-2.89) | <.001 |
| Del(13q)/monosomy 13 | 1.85 (1.31-2.60) | <.001 |
| Including hypodiploid karyotype | ||
| R-ISS III vs I | 2.86 (1.90-4.30) | <.001 |
| R-ISS II vs I | 1.54 (1.11-2.14) | .010 |
| Age ≥70 y | 2.27 (1.80-2.86) | <.001 |
| Hypodiploid | 2.36 (1.35-4.12) | .003 |
| Including nonhyperdiploid karyotype | ||
| R-ISS III vs I | 2.63 (1.74-3.98) | <.001 |
| R-ISS II vs I | 1.49 (1.07-2.08) | .017 |
| Age ≥70 y | 2.34 (1.85-2.95) | <.001 |
| Nonhyperdiploid | 1.90 (1.34-2.68) | <.001 |
| Including mCG gain 1q | ||
| R-ISS III vs I | 2.92 (1.95-4.37) | <.001 |
| R-ISS II vs I | 1.55 (1.11-2.15) | .009 |
| Age ≥70 y | 2.22 (1.76-2.80) | <.001 |
| mCG gain 1q | 1.61 (1.13-2.28) | .008 |
| Including FISH gain 1q | ||
| R-ISS III vs I | 2.50 (1.62-3.85) | <.001 |
| R-ISS II vs 1 | 1.28 (0.89-1.82) | .179 |
| Age ≥70 y | 2.19 (1.71-2.82) | <.001 |
| FISH gain 1q | 1.38 (1.06-1.81) | .017 |
| Including PCPro ≥2% | ||
| R-ISS III vs I | 2.83 (1.89-4.23) | <.001 |
| R-ISS II vs 1 | 1.53 (1.10-2.13) | .011 |
| Age ≥70 y | 2.21 (1.75-2.78) | <.001 |
| PCPro ≥2% | 1.60 (1.23-2.08) | .001 |
| Multivariable analysis . | Hazard ratio (95% CI) . | P . |
|---|---|---|
| Excluding mCG (base model) | ||
| R-ISS III vs I | 3.15 (2.11-4.69) | <.001 |
| R-ISS II vs I | 1.57 (1.13-2.18) | .007 |
| Age ≥70 y | 2.20 (1.75-2.78) | <.001 |
| Including mCG | ||
| R-ISS III vs I | 2.83 (1.89-4.23) | <.001 |
| R-ISS II vs I | 1.51 (1.08-2.10) | .015 |
| Age ≥70 y | 2.28 (1.81-2.88) | <.001 |
| Abnormal mCG | 1.61 (1.25-2.07) | <.001 |
| Including del(13q)/monosomy 13 | ||
| R-ISS III vs I | 2.79 (1.86-4.19) | <.001 |
| R-ISS II vs I | 1.51 (1.09-2.11) | .014 |
| Age ≥70 y | 2.29 (1.81-2.89) | <.001 |
| Del(13q)/monosomy 13 | 1.85 (1.31-2.60) | <.001 |
| Including hypodiploid karyotype | ||
| R-ISS III vs I | 2.86 (1.90-4.30) | <.001 |
| R-ISS II vs I | 1.54 (1.11-2.14) | .010 |
| Age ≥70 y | 2.27 (1.80-2.86) | <.001 |
| Hypodiploid | 2.36 (1.35-4.12) | .003 |
| Including nonhyperdiploid karyotype | ||
| R-ISS III vs I | 2.63 (1.74-3.98) | <.001 |
| R-ISS II vs I | 1.49 (1.07-2.08) | .017 |
| Age ≥70 y | 2.34 (1.85-2.95) | <.001 |
| Nonhyperdiploid | 1.90 (1.34-2.68) | <.001 |
| Including mCG gain 1q | ||
| R-ISS III vs I | 2.92 (1.95-4.37) | <.001 |
| R-ISS II vs I | 1.55 (1.11-2.15) | .009 |
| Age ≥70 y | 2.22 (1.76-2.80) | <.001 |
| mCG gain 1q | 1.61 (1.13-2.28) | .008 |
| Including FISH gain 1q | ||
| R-ISS III vs I | 2.50 (1.62-3.85) | <.001 |
| R-ISS II vs 1 | 1.28 (0.89-1.82) | .179 |
| Age ≥70 y | 2.19 (1.71-2.82) | <.001 |
| FISH gain 1q | 1.38 (1.06-1.81) | .017 |
| Including PCPro ≥2% | ||
| R-ISS III vs I | 2.83 (1.89-4.23) | <.001 |
| R-ISS II vs 1 | 1.53 (1.10-2.13) | .011 |
| Age ≥70 y | 2.21 (1.75-2.78) | <.001 |
| PCPro ≥2% | 1.60 (1.23-2.08) | .001 |