BAGS defined subtype analysis
| Group . | Pre-BI (%) . | Pre-BII (%) . | Im (%) . | N (%) . | M (%) . | PC (%) . | UC (%) . | Sum . |
|---|---|---|---|---|---|---|---|---|
| Frequencies across data sets (P = .90) | ||||||||
| UAMS | 3 (1) | 29 (5) | 58 (10) | 143 (26) | 219 (39) | 23 (4) | 84 (15) | 559 |
| Hovon 65 | 2 (1) | 19 (6) | 45 (14) | 61 (19) | 134 (42) | 11 | 48 (15) | 320 |
| Myeloma IX | 1 (0) | 14 (6) | 23 (9) | 59 (24) | 105 (43) | 8 (3) | 37 (15) | 247 |
| IFM-DFCI | 2 (1) | 11 (6) | 21 (12) | 38 (22) | 68 (40) | 4 (2) | 26 (15) | 170 |
| Sum* | 8 (1) | 75 (6) | 147 (11) | 302 (23) | 528 (41) | 46 (4) | 196 (15) | 1296 |
| Association with the TC classification (P < .001) | ||||||||
| 4p16 | 1 (1) | 21 (12) | 7 (4) | 45 (25) | 78 (44) | 3 (2) | 22 (12) | 177 |
| MAF | 2 (2) | 4 (5) | 12 (15) | 25 (30) | 31 (38) | 1 (1) | 7 (9) | 82 |
| 6p21 | 1 (1) | 2 (2) | 12 (14) | 19 (22) | 36 (42) | 2 (2) | 14 (16) | 86 |
| 11q13 | 0 (0) | 3 (2) | 11 (7) | 46 (29) | 81 (51) | 4 (2) | 15 (9) | 160 |
| D1 | 2 (0) | 11 (3) | 63 (15) | 89 (21) | 157 (37) | 19 (5) | 81 (19) | 422 |
| D1plusD2 | 0 (0) | 4 (20) | 2 (10) | 2 (10) | 9 (45) | 0 (0) | 3 (15) | 20 |
| D2 | 1 (1) | 16 (13) | 12 (10) | 15 (12) | 53 (44) | 7 (6) | 17 (14) | 121 |
| Unclassified | 1 (0) | 12 (5) | 28 (12) | 60 (26) | 81 (36) | 10 (4) | 36 (16) | 228 |
| Sum | 8 (1) | 73 (6) | 147 (11) | 301 (23) | 526 (41) | 46 (4) | 195 (15) | 1296 |
| ISS stage III with increased frequencies in the Pre-BII and M subtypes (P = .032) | ||||||||
| Stage I | 2 (0) | 8 (2) | 51 (12) | 115 (28) | 149 (36) | 18 (4) | 72 (17) | 415 |
| Stage II | 1 (0) | 18 (7) | 25 (9) | 65 (24) | 105 (39) | 15 (6) | 39 (15) | 268 |
| Stage III | 2 (1) | 19 (10) | 22 (11) | 33 (17) | 89 (46) | 5 (3) | 23 (12) | 193 |
| NA | 1 (0) | 17 (7) | 28 (11) | 50 (20) | 115 (46) | 4 (2) | 35 (14) | 250 |
| Sum | 6 (1) | 62 (6) | 126 (11) | 263 (23) | 458 (41) | 42 (4) | 169 (15) | 1126 |
| Group . | Pre-BI (%) . | Pre-BII (%) . | Im (%) . | N (%) . | M (%) . | PC (%) . | UC (%) . | Sum . |
|---|---|---|---|---|---|---|---|---|
| Frequencies across data sets (P = .90) | ||||||||
| UAMS | 3 (1) | 29 (5) | 58 (10) | 143 (26) | 219 (39) | 23 (4) | 84 (15) | 559 |
| Hovon 65 | 2 (1) | 19 (6) | 45 (14) | 61 (19) | 134 (42) | 11 | 48 (15) | 320 |
| Myeloma IX | 1 (0) | 14 (6) | 23 (9) | 59 (24) | 105 (43) | 8 (3) | 37 (15) | 247 |
| IFM-DFCI | 2 (1) | 11 (6) | 21 (12) | 38 (22) | 68 (40) | 4 (2) | 26 (15) | 170 |
| Sum* | 8 (1) | 75 (6) | 147 (11) | 302 (23) | 528 (41) | 46 (4) | 196 (15) | 1296 |
| Association with the TC classification (P < .001) | ||||||||
| 4p16 | 1 (1) | 21 (12) | 7 (4) | 45 (25) | 78 (44) | 3 (2) | 22 (12) | 177 |
| MAF | 2 (2) | 4 (5) | 12 (15) | 25 (30) | 31 (38) | 1 (1) | 7 (9) | 82 |
| 6p21 | 1 (1) | 2 (2) | 12 (14) | 19 (22) | 36 (42) | 2 (2) | 14 (16) | 86 |
| 11q13 | 0 (0) | 3 (2) | 11 (7) | 46 (29) | 81 (51) | 4 (2) | 15 (9) | 160 |
| D1 | 2 (0) | 11 (3) | 63 (15) | 89 (21) | 157 (37) | 19 (5) | 81 (19) | 422 |
| D1plusD2 | 0 (0) | 4 (20) | 2 (10) | 2 (10) | 9 (45) | 0 (0) | 3 (15) | 20 |
| D2 | 1 (1) | 16 (13) | 12 (10) | 15 (12) | 53 (44) | 7 (6) | 17 (14) | 121 |
| Unclassified | 1 (0) | 12 (5) | 28 (12) | 60 (26) | 81 (36) | 10 (4) | 36 (16) | 228 |
| Sum | 8 (1) | 73 (6) | 147 (11) | 301 (23) | 526 (41) | 46 (4) | 195 (15) | 1296 |
| ISS stage III with increased frequencies in the Pre-BII and M subtypes (P = .032) | ||||||||
| Stage I | 2 (0) | 8 (2) | 51 (12) | 115 (28) | 149 (36) | 18 (4) | 72 (17) | 415 |
| Stage II | 1 (0) | 18 (7) | 25 (9) | 65 (24) | 105 (39) | 15 (6) | 39 (15) | 268 |
| Stage III | 2 (1) | 19 (10) | 22 (11) | 33 (17) | 89 (46) | 5 (3) | 23 (12) | 193 |
| NA | 1 (0) | 17 (7) | 28 (11) | 50 (20) | 115 (46) | 4 (2) | 35 (14) | 250 |
| Sum | 6 (1) | 62 (6) | 126 (11) | 263 (23) | 458 (41) | 42 (4) | 169 (15) | 1126 |
The BAGS-defined subtype analysis was performed across 4 different clinical cohorts (N = 1296 cases) following assignment of the data sets according to the restricted multinomial classifier.
ISS, International Staging System; UC, unclassified.