Cox proportional hazards regression analysis
| . | Univariate . | Multivariate . | ||||
|---|---|---|---|---|---|---|
| . | Hazard ratio . | 95% CI . | P . | Hazard ratio . | 95% CI . | P . |
| Combined PFS, n = 642, number of events = 311 | ||||||
| Pre-BII | 1 | — | — | 1 | — | — |
| Im | 0.45 | 0.26-0.76 | .0032 | 0.48 | 0.28-0.83 | 00085 |
| N | 0.41 | 0.25-0.66 | <.001 | 0.39 | 0.24-0.63 | <.001 |
| M | 0.61 | 0.39-0.95 | .027 | 0.58 | 0.37-0.92 | .02 |
| PC | 0.28 | 0.13-0.6 | <.001 | 0.3 | 0.14-0.64 | .0018 |
| 4p16 | 1 | — | — | 1 | — | — |
| MAF | 0.47 | 0.29-0.77 | .0026 | 0.53 | 0.32-0.86 | .011 |
| 6p21 | 0.23 | 0.07-0.73 | .013 | 0.17 | 0.05-0.54 | .0027 |
| 11q13 | 0.36 | 0.26-0.52 | <.001 | 0.31 | 0.22-0.45 | <.001 |
| D1 | 0.35 | 0.26-0.47 | <.001 | 0.3 | 0.22-0.41 | <.001 |
| D1plusD2 | 0.27 | 0.12-0.63 | .0024 | 0.27 | 0.12-0.62 | .0021 |
| D2 | 0.38 | 0.25-0.57 | <.001 | 0.25 | 0.16-0.39 | <.001 |
| Hovon65 | 1 | — | — | 1 | — | — |
| MyelomaIX | 1.16 | 0.84-1.6 | .38 | 1.15 | 0.83-1.59 | .41 |
| UAMS | 0.37 | 0.29-0.48 | <.001 | 0.33 | 0.26-0.42 | <.001 |
| Combined OS, n = 642, number of events = 236 | ||||||
| Pre-BII | 1 | — | — | 1 | — | — |
| Im | 0.31 | 0.18-0.51 | <.001 | 0.36 | 0.21-0.62 | <.001 |
| N | 0.19 | 0.12-0.3 | <.001 | 0.19 | 0.12-0.31 | <.001 |
| M | 0.33 | 0.22-0.5 | <.001 | 0.34 | 0.23-0.52 | <.001 |
| PC | 0.1 | 0.03-0.28 | <.001 | 0.11 | 0.04-0.32 | <.001 |
| 4p16 | 1 | — | — | 1 | — | — |
| MAF | 0.53 | 0.3-0.93 | .027 | 0.59 | 0.34-1.05 | .072 |
| 6p21 | 0.43 | 0.13-1.36 | .15 | 0.51 | 0.16-1.65 | .26 |
| 11q13 | 0.48 | 0.33-0.71 | <.001 | 0.51 | 0.35-0.76 | <.001 |
| D1 | 0.37 | 0.26-0.51 | <.001 | 0.39 | 0.28-0.55 | <.001 |
| D1plusD2 | 0.41 | 0.17-1.02 | .056 | 0.31 | 0.12-0.78 | .013 |
| D2 | 0.53 | 0.34-0.83 | .0056 | 0.47 | 0.3-0.75 | .0014 |
| Hovon65 | 1 | — | — | 1 | — | — |
| MyelomaIX | 1.23 | 0.81-1.85 | .33 | 1.24 | 0.82-1.88 | .31 |
| UAMS | 0.91 | 0.68-1.21 | .5 | 0.87 | 0.65-1.17 | .35 |
| . | Univariate . | Multivariate . | ||||
|---|---|---|---|---|---|---|
| . | Hazard ratio . | 95% CI . | P . | Hazard ratio . | 95% CI . | P . |
| Combined PFS, n = 642, number of events = 311 | ||||||
| Pre-BII | 1 | — | — | 1 | — | — |
| Im | 0.45 | 0.26-0.76 | .0032 | 0.48 | 0.28-0.83 | 00085 |
| N | 0.41 | 0.25-0.66 | <.001 | 0.39 | 0.24-0.63 | <.001 |
| M | 0.61 | 0.39-0.95 | .027 | 0.58 | 0.37-0.92 | .02 |
| PC | 0.28 | 0.13-0.6 | <.001 | 0.3 | 0.14-0.64 | .0018 |
| 4p16 | 1 | — | — | 1 | — | — |
| MAF | 0.47 | 0.29-0.77 | .0026 | 0.53 | 0.32-0.86 | .011 |
| 6p21 | 0.23 | 0.07-0.73 | .013 | 0.17 | 0.05-0.54 | .0027 |
| 11q13 | 0.36 | 0.26-0.52 | <.001 | 0.31 | 0.22-0.45 | <.001 |
| D1 | 0.35 | 0.26-0.47 | <.001 | 0.3 | 0.22-0.41 | <.001 |
| D1plusD2 | 0.27 | 0.12-0.63 | .0024 | 0.27 | 0.12-0.62 | .0021 |
| D2 | 0.38 | 0.25-0.57 | <.001 | 0.25 | 0.16-0.39 | <.001 |
| Hovon65 | 1 | — | — | 1 | — | — |
| MyelomaIX | 1.16 | 0.84-1.6 | .38 | 1.15 | 0.83-1.59 | .41 |
| UAMS | 0.37 | 0.29-0.48 | <.001 | 0.33 | 0.26-0.42 | <.001 |
| Combined OS, n = 642, number of events = 236 | ||||||
| Pre-BII | 1 | — | — | 1 | — | — |
| Im | 0.31 | 0.18-0.51 | <.001 | 0.36 | 0.21-0.62 | <.001 |
| N | 0.19 | 0.12-0.3 | <.001 | 0.19 | 0.12-0.31 | <.001 |
| M | 0.33 | 0.22-0.5 | <.001 | 0.34 | 0.23-0.52 | <.001 |
| PC | 0.1 | 0.03-0.28 | <.001 | 0.11 | 0.04-0.32 | <.001 |
| 4p16 | 1 | — | — | 1 | — | — |
| MAF | 0.53 | 0.3-0.93 | .027 | 0.59 | 0.34-1.05 | .072 |
| 6p21 | 0.43 | 0.13-1.36 | .15 | 0.51 | 0.16-1.65 | .26 |
| 11q13 | 0.48 | 0.33-0.71 | <.001 | 0.51 | 0.35-0.76 | <.001 |
| D1 | 0.37 | 0.26-0.51 | <.001 | 0.39 | 0.28-0.55 | <.001 |
| D1plusD2 | 0.41 | 0.17-1.02 | .056 | 0.31 | 0.12-0.78 | .013 |
| D2 | 0.53 | 0.34-0.83 | .0056 | 0.47 | 0.3-0.75 | .0014 |
| Hovon65 | 1 | — | — | 1 | — | — |
| MyelomaIX | 1.23 | 0.81-1.85 | .33 | 1.24 | 0.82-1.88 | .31 |
| UAMS | 0.91 | 0.68-1.21 | .5 | 0.87 | 0.65-1.17 | .35 |
Cox proportional hazards regression analysis in the meta–data set for BAGS subtypes based on PFS and OS, demonstrating added independent significance to the TC classification staging system. Columns on the left show results for a univariate analysis with each of the covariates, whereas columns on the right show results from the multivariate model. The Pre-BI class was dropped from the analysis because of too few observations in this group.
CI, confidence interval.