D-dimer test accuracy in a low- and high-prevalence population
| Test result . | Number of results per 1000 patients tested (95% CI) . | Number of participants (studies) . | Quality of the evidence (GRADE) . | |
|---|---|---|---|---|
| Prevalence 10%* . | Prevalence 40%*† . | |||
| True positives | 96 (87-99) | 385 (348-396) | 482 (3) | ⨁⨁⨁◯ Moderate‡§ |
| False negatives | 4 (1-13) | 15 (4-52) | ||
| True negatives | 425 (384-467) | 284 (256-312) | 482 (3) | ⨁⨁⨁◯ Moderate‡§ |
| False positives | 475 (433-516) | 316 (286-344) | ||
| Inconclusive test results | Not reported | |||
| Complications arising from the diagnostic test | Not reported | |||
| Test result . | Number of results per 1000 patients tested (95% CI) . | Number of participants (studies) . | Quality of the evidence (GRADE) . | |
|---|---|---|---|---|
| Prevalence 10%* . | Prevalence 40%*† . | |||
| True positives | 96 (87-99) | 385 (348-396) | 482 (3) | ⨁⨁⨁◯ Moderate‡§ |
| False negatives | 4 (1-13) | 15 (4-52) | ||
| True negatives | 425 (384-467) | 284 (256-312) | 482 (3) | ⨁⨁⨁◯ Moderate‡§ |
| False positives | 475 (433-516) | 316 (286-344) | ||
| Inconclusive test results | Not reported | |||
| Complications arising from the diagnostic test | Not reported | |||
An interactive summary of findings table is available at: https://gdt.gradepro.org/presentations/#/isof/isof_257cf98c-83bb-488f-b8dd-3c57549fb78e-1590262290785?_k=ad41h5. Patient or population: patients with suspected UEDVT. Setting: inpatient and outpatient. Pooled sensitivity: 0.96 (95% CI, 0.87-0.99). Pooled specificity: 0.47 (95% CI, 0.43-0.52).
Data from Constans et al.14
Data from Kleinjan et al.18
Not downgraded for risk of bias, although few studies had unclear information on the standard reference test.
Downgraded for imprecision; small number of patients included in studies.