Questions prioritized by the ASH guideline panel on management of acute and chronic pain
| Prioritized questions . |
|---|
| Q1. In children and adults who seek treatment of acute pain, should a standardized protocol be used that includes (1) reduced time to first dose (<1 h from arrival) in addition to more frequent reassessment and dosing of pain medication (<30 min) and (2) tailored dosing (vs weight-based dosing)? |
| Q2. Should nonopioid pharmacological therapies either in addition to or instead of opioids or other usual care interventions be used for the treatment of acute pain in children and adults with SCD? |
| Q3. Should nonpharmacological therapies in addition to pharmacological therapies be used for the treatment of acute pain in children and adults with SCD? |
| Q4. Should a hospital-based entity such as a day hospital or observation unit compared with regular ED care be used for children and adults with SCD who seek treatment of acute pain? |
| Q5. Should a combination of continuous basal opioid infusion with on-demand dosing vs on-demand opioid dosing alone or scheduled intermittent opioid dosing be used for children and adults with SCD hospitalized for the treatment of acute pain? |
| Q6. Should nonopioid pharmacological therapy, either in addition to or instead of opioids or other usual care interventions, be used for children and adults with SCD and chronic pain with another identifiable cause (eg, avascular necrosis, leg ulcers)? |
| Q7. Should nonopioid pharmacological therapy, either in addition to or instead of opioids or other usual care interventions, be used for children and adults with SCD and chronic pain with no identifiable cause beyond SCD? |
| Q8. Should nonpharmacological therapies be used in addition to pharmacological therapy for the treatment of chronic pain in children and adults with SCD? |
| Q9. Should chronic opioid therapy vs no chronic opioid therapy or periodic opioid therapy be used in patients with SCD who have chronic pain? |
| Q10. Should chronic monthly transfusion therapy to suppress hemoglobin S levels of <30% vs no transfusions or on-demand transfusions be used for children and adults with SCD who have recurrent acute pain and/or chronic pain? |
| Prioritized questions . |
|---|
| Q1. In children and adults who seek treatment of acute pain, should a standardized protocol be used that includes (1) reduced time to first dose (<1 h from arrival) in addition to more frequent reassessment and dosing of pain medication (<30 min) and (2) tailored dosing (vs weight-based dosing)? |
| Q2. Should nonopioid pharmacological therapies either in addition to or instead of opioids or other usual care interventions be used for the treatment of acute pain in children and adults with SCD? |
| Q3. Should nonpharmacological therapies in addition to pharmacological therapies be used for the treatment of acute pain in children and adults with SCD? |
| Q4. Should a hospital-based entity such as a day hospital or observation unit compared with regular ED care be used for children and adults with SCD who seek treatment of acute pain? |
| Q5. Should a combination of continuous basal opioid infusion with on-demand dosing vs on-demand opioid dosing alone or scheduled intermittent opioid dosing be used for children and adults with SCD hospitalized for the treatment of acute pain? |
| Q6. Should nonopioid pharmacological therapy, either in addition to or instead of opioids or other usual care interventions, be used for children and adults with SCD and chronic pain with another identifiable cause (eg, avascular necrosis, leg ulcers)? |
| Q7. Should nonopioid pharmacological therapy, either in addition to or instead of opioids or other usual care interventions, be used for children and adults with SCD and chronic pain with no identifiable cause beyond SCD? |
| Q8. Should nonpharmacological therapies be used in addition to pharmacological therapy for the treatment of chronic pain in children and adults with SCD? |
| Q9. Should chronic opioid therapy vs no chronic opioid therapy or periodic opioid therapy be used in patients with SCD who have chronic pain? |
| Q10. Should chronic monthly transfusion therapy to suppress hemoglobin S levels of <30% vs no transfusions or on-demand transfusions be used for children and adults with SCD who have recurrent acute pain and/or chronic pain? |