Comparison of allele frequency between iTTP patients and controls in Japan
| HLA type . | Allele frequency in iTTP patients (%) n = 52 . | Allele frequency in controls (%) n = 516 . | P (observed) . | P (corrected) . | OR (95% CI) . |
|---|---|---|---|---|---|
| DRB1 | |||||
| DRB1*08:03 | 17.3 | 6.4 | 2.86 × 10−4 | .005 | 3.06 (1.63-5.51) |
| DRB1*15:01 | 2.9 | 11.6 | 4.22 × 10−3 | .076 | 0.23 (0.05-0.70) |
| DRB3/4/5 | |||||
| Blank | 27.9 | 14.3 | 9.13 × 10−4 | .007 | 2.30 (1.40-3.72) |
| DRB5*01:01 | 2.9 | 11.6 | 4.22 × 10−3 | .034 | 0.23 (0.05-0.70) |
| DQA1 | |||||
| DQA1*01:03 | 29.8 | 15.9 | 8.94 × 10−4 | .006 | 2.25 (1.38-3.60) |
| DQB1 | |||||
| DQB1*06:01 | 29.8 | 14.9 | 2.49 × 10−4 | .003 | 2.41 (1.48-3.88) |
| HLA type . | Allele frequency in iTTP patients (%) n = 52 . | Allele frequency in controls (%) n = 516 . | P (observed) . | P (corrected) . | OR (95% CI) . |
|---|---|---|---|---|---|
| DRB1 | |||||
| DRB1*08:03 | 17.3 | 6.4 | 2.86 × 10−4 | .005 | 3.06 (1.63-5.51) |
| DRB1*15:01 | 2.9 | 11.6 | 4.22 × 10−3 | .076 | 0.23 (0.05-0.70) |
| DRB3/4/5 | |||||
| Blank | 27.9 | 14.3 | 9.13 × 10−4 | .007 | 2.30 (1.40-3.72) |
| DRB5*01:01 | 2.9 | 11.6 | 4.22 × 10−3 | .034 | 0.23 (0.05-0.70) |
| DQA1 | |||||
| DQA1*01:03 | 29.8 | 15.9 | 8.94 × 10−4 | .006 | 2.25 (1.38-3.60) |
| DQB1 | |||||
| DQB1*06:01 | 29.8 | 14.9 | 2.49 × 10−4 | .003 | 2.41 (1.48-3.88) |
No disease-related alleles were identified in the A, B, C, or DPB1 loci.