Table 3. Analysis of posttransplant risk... | American Society of Hematology

Table 3.

Analysis of posttransplant risk factors for the development of TA-TMA

Variables	Univariate		Multivariate
Variables	HR (95% CI)	P	HR (95% CI)	P
Grade 3-4 aGVHD
N	Reference		Reference
Y	4.62 (2.98-7.14)	<.01*	4.02 (2.36-6.83)	<.01*
Bacterial infection
N	Reference
Y	1.1 (0.81-1.74)	.37
Aspergillus infection
N	Reference		Reference
Y	2.41 (1.32-4.39)	<.01*	2.29 (1.15-4.54)	.01*
Candida infection
N	Reference
Y	1.36 (0.43-4.30)	.60
CMV infection
N	Reference
Y	1.57 (0.64-3.76)	.32
CMV reactivation
N	Reference		Reference
Y	2.01 (1.31-3.09)	<.01*	1.51 (0.92-2.47)	.09
Hemorrhagic cystitis
N	Reference		Reference
Y	1.91 (1.00-3.64)	.05	1.45 (0.69-3.07)	.32
VOD/SOS
N	Reference		Reference
Y	6.39 (3.66-11.1)	<.01*	4.47 (2.25-8.87)	<.01*

Variables	Univariate		Multivariate
Variables	HR (95% CI)	P	HR (95% CI)	P
Grade 3-4 aGVHD
N	Reference		Reference
Y	4.62 (2.98-7.14)	<.01*	4.02 (2.36-6.83)	<.01*
Bacterial infection
N	Reference
Y	1.1 (0.81-1.74)	.37
Aspergillus infection
N	Reference		Reference
Y	2.41 (1.32-4.39)	<.01*	2.29 (1.15-4.54)	.01*
Candida infection
N	Reference
Y	1.36 (0.43-4.30)	.60
CMV infection
N	Reference
Y	1.57 (0.64-3.76)	.32
CMV reactivation
N	Reference		Reference
Y	2.01 (1.31-3.09)	<.01*	1.51 (0.92-2.47)	.09
Hemorrhagic cystitis
N	Reference		Reference
Y	1.91 (1.00-3.64)	.05	1.45 (0.69-3.07)	.32
VOD/SOS
N	Reference		Reference
Y	6.39 (3.66-11.1)	<.01*	4.47 (2.25-8.87)	<.01*

Multivariate analysis was performed including significant pre-HSCT factors (age, PS, HCT-CI, donor source, and HLA mismatch).

Statistically significant.