Correlation between 14-3-3 isoforms and PI sensitivity
| Gene name . | Protein . | PI sensitivity correlation in MM cell lines . | |||
|---|---|---|---|---|---|
| BTZ . | CFZ . | ||||
| r . | P . | r . | P . | ||
| YWHAS/SFN | 14-3-3 σ | −0.02558 | .9251 | 0.3646 | .244 |
| YWHAB | 14-3-3 β | −0.1124 | .6786 | 0.1622 | .6145 |
| YWHAE | 14-3-3 ε | −0.5164 | .0406 | −0.74 | .0059 |
| YWHAG | 14-3-3 γ | 0.2677 | .3161 | 0.1756 | .5851 |
| YWHAH | 14-3-3 η | −0.5622 | .0234 | −0.4095 | .1862 |
| YWHAQ | 14-3-3 τ | −0.1914 | .4776 | −0.1329 | .6806 |
| YWHAZ | 14-3-3 ζ | 0.1478 | .5849 | 0.1166 | .7181 |
| Gene name . | Protein . | PI sensitivity correlation in MM cell lines . | |||
|---|---|---|---|---|---|
| BTZ . | CFZ . | ||||
| r . | P . | r . | P . | ||
| YWHAS/SFN | 14-3-3 σ | −0.02558 | .9251 | 0.3646 | .244 |
| YWHAB | 14-3-3 β | −0.1124 | .6786 | 0.1622 | .6145 |
| YWHAE | 14-3-3 ε | −0.5164 | .0406 | −0.74 | .0059 |
| YWHAG | 14-3-3 γ | 0.2677 | .3161 | 0.1756 | .5851 |
| YWHAH | 14-3-3 η | −0.5622 | .0234 | −0.4095 | .1862 |
| YWHAQ | 14-3-3 τ | −0.1914 | .4776 | −0.1329 | .6806 |
| YWHAZ | 14-3-3 ζ | 0.1478 | .5849 | 0.1166 | .7181 |
Pearson correlation analysis between expression of 14-3-3 proteins and sensitivity to BTZ and CFZ in a panel of MM cell lines. A Pearson correlation coefficient, r, value greater than 0 indicates a positive association; less than 0 indicates a negative association; 0 indicates no association between the 2 variables. Significant correlations are shown in bold and italics.