Characteristics of 7 patients with primary GF
| Patient . | Arm . | Age, y . | Sex . | No. of CBU . | Disease . | Status at transplant . | MRD status . | Infused TNC/kg, ×107* . | Infused CD34/kg, ×106* . | Viral infections . | Outcomes (death, second transplant) . |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 1 | 47.6 | F | 2 | AML | CR1 | − | 1.65 1.60 | 0.05 0.03 | HAdV | Death |
| 2 | 1 | 33.5 | M | 2 | MDS | CR1 | − | 2.17 2.0 | 0.06 | None | Death |
| 3† | 2 | 26.8 | M | 2 | ALL | CR≥3 | − | 3.32 2.47 | 0.26 0.23 | CMV, BK virus, RSV, coronavirus | Alive‡ |
| 4† | 2 | 56.6 | M | 2 | MDS | Active disease§ | + | 2.2 1.7 | 0.24 0.18 | None | Death s/p MMURD |
| 5 | 2 | 61.2 | F | 2 | MDS | REFR | + | 2.47 2.31 | 0.09 0.05 | CMV | Alive|| |
| 6 | 2 | 58.9 | M | 2 | AML | CR1 | − | 2.12 2.03 | 0.1 0.08 | None | Death s/p HAPLO |
| 7& | 2 | 54.5 | M | 2 | MDS | Active disease§ | + | 2.3 2.01 | 0.14 0.04 | None | Alive s/p HAPLO |
| Patient . | Arm . | Age, y . | Sex . | No. of CBU . | Disease . | Status at transplant . | MRD status . | Infused TNC/kg, ×107* . | Infused CD34/kg, ×106* . | Viral infections . | Outcomes (death, second transplant) . |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 1 | 47.6 | F | 2 | AML | CR1 | − | 1.65 1.60 | 0.05 0.03 | HAdV | Death |
| 2 | 1 | 33.5 | M | 2 | MDS | CR1 | − | 2.17 2.0 | 0.06 | None | Death |
| 3† | 2 | 26.8 | M | 2 | ALL | CR≥3 | − | 3.32 2.47 | 0.26 0.23 | CMV, BK virus, RSV, coronavirus | Alive‡ |
| 4† | 2 | 56.6 | M | 2 | MDS | Active disease§ | + | 2.2 1.7 | 0.24 0.18 | None | Death s/p MMURD |
| 5 | 2 | 61.2 | F | 2 | MDS | REFR | + | 2.47 2.31 | 0.09 0.05 | CMV | Alive|| |
| 6 | 2 | 58.9 | M | 2 | AML | CR1 | − | 2.12 2.03 | 0.1 0.08 | None | Death s/p HAPLO |
| 7& | 2 | 54.5 | M | 2 | MDS | Active disease§ | + | 2.3 2.01 | 0.14 0.04 | None | Alive s/p HAPLO |
−, negative; +, positive; BK virus, human polyomavirus; CBU, cord blood unit; CR≥3, complete remission 3 or more; F, female; HAdV, human adenovirus; HAPLO, haploidentical donor transplant; M, male; MMURD, mismatched unrelated donor transplant; REFR, primary refractory; RSV, respiratory syncytial virus; s/p, status post.
Prethaw, by units.
Patient received higher dose FLU regimen.
Patient recovered counts at day +66. Relapse treated with CAR-T cell.
Patients had blast by FLOW and morphology and were cytogenetic positive at the time of transplant.
Patient recovered counts at day +89.