Renal pathological data
| . | All (n = 220) . | LCDD (n = 180) . | HCDD (n = 22) . | LHCDD (n = 18) . |
|---|---|---|---|---|
| Light microscopy, n (%) | ||||
| Nodular glomerulosclerosis | 131 (60) | 95 (53) | 22 (100)* | 14 (78)† |
| TBM thickening | 180 (82) | 151 (84) | 15 (68) | 14 (78) |
| Tubular atrophy and interstitial fibrosis | ||||
| Mild/moderate | 126 (57) | 101 (56) | 13 (59) | 12 (67) |
| Severe | 68 (31) | 59 (33) | 4 (18) | 5 (28) |
| Arteriosclerosis | ||||
| Mild/moderate | 103 (47) | 82 (46) | 11 (50) | 7 (39) |
| Severe | 32 (15) | 26 (14.4) | 3 (13.6) | 3 (16.7) |
| CN | 58 (26) | 58 (32) | 0* | 0† |
| Amyloidosis | 4 (2) | 4 (2) | 0 | 0 |
| IF, n (%) | ||||
| Linear TBM deposits | 220 (100) | 180 (100) | 22 (100) | 18 (100) |
| Linear GBM deposits | 180 (82) | 143 (79) | 20 (90) | 17 (94) |
| Light chain isotype (κ/λ) | 157/41 | 143/37 | 0/0 | 14/4 |
| Heavy chain isotype (γ/α/μ) | 35/4/1 | 0/0/0 | 18/4/0 | 17/0/1 |
| γ HC subtypes (γ1/γ3/γ4)‡ | — | — | 14/1/3 | 5/0/1 |
| EM, n (%) | 56 (25.5) | 38 (21.1) | 11 (50) | 7 (38.9) |
| GBM deposits | 34 (61) | 19 (50) | 11 (100)* | 4 (57) |
| TBM deposits | 39 (69) | 28 (74) | 11 (100) | 2 (29) |
| Mesangium | 25 (45) | 15 (39) | 9 (82)* | 1 (14) |
| Vascular | 10 (18) | 7 (18) | 3 (27) | 0 |
| . | All (n = 220) . | LCDD (n = 180) . | HCDD (n = 22) . | LHCDD (n = 18) . |
|---|---|---|---|---|
| Light microscopy, n (%) | ||||
| Nodular glomerulosclerosis | 131 (60) | 95 (53) | 22 (100)* | 14 (78)† |
| TBM thickening | 180 (82) | 151 (84) | 15 (68) | 14 (78) |
| Tubular atrophy and interstitial fibrosis | ||||
| Mild/moderate | 126 (57) | 101 (56) | 13 (59) | 12 (67) |
| Severe | 68 (31) | 59 (33) | 4 (18) | 5 (28) |
| Arteriosclerosis | ||||
| Mild/moderate | 103 (47) | 82 (46) | 11 (50) | 7 (39) |
| Severe | 32 (15) | 26 (14.4) | 3 (13.6) | 3 (16.7) |
| CN | 58 (26) | 58 (32) | 0* | 0† |
| Amyloidosis | 4 (2) | 4 (2) | 0 | 0 |
| IF, n (%) | ||||
| Linear TBM deposits | 220 (100) | 180 (100) | 22 (100) | 18 (100) |
| Linear GBM deposits | 180 (82) | 143 (79) | 20 (90) | 17 (94) |
| Light chain isotype (κ/λ) | 157/41 | 143/37 | 0/0 | 14/4 |
| Heavy chain isotype (γ/α/μ) | 35/4/1 | 0/0/0 | 18/4/0 | 17/0/1 |
| γ HC subtypes (γ1/γ3/γ4)‡ | — | — | 14/1/3 | 5/0/1 |
| EM, n (%) | 56 (25.5) | 38 (21.1) | 11 (50) | 7 (38.9) |
| GBM deposits | 34 (61) | 19 (50) | 11 (100)* | 4 (57) |
| TBM deposits | 39 (69) | 28 (74) | 11 (100) | 2 (29) |
| Mesangium | 25 (45) | 15 (39) | 9 (82)* | 1 (14) |
| Vascular | 10 (18) | 7 (18) | 3 (27) | 0 |