Drugs that may trigger AHA in G6PD-deficient patients
| Definite risk of AHA . | “Possible” risk of AHA . | Possible association (less likely) . |
|---|---|---|
| Antimalarial drugs | ||
| Dapsone-containing combinations* | Chloroquine | |
| Pamaquine* | Quinidine | |
| Primaquine* | Quinine | |
| Tafenoquine | ||
| Other drugs | ||
| Ciprofloxacin | Aspirin† | Chloramphenicol |
| Glibenclamide‡ | Menadiol sodium phosphate | Dimercaptosuccinic acid |
| Methylthioninium chloride*,§ | Sulfadiazine | Glibenclamide |
| Moxifloxacin | Sulfasalazine | Mepacrine |
| Nalidixic acid | Sulfonylureas | Vitamin K analogs |
| Niridazole | Tolonium chloride|| | |
| Nitrofurantoin*,¶ | ||
| Norfloxacin | ||
| Ofloxacin | ||
| Phenazopyridine# | ||
| Rasburicase and pegloticase34,* | ||
| Sulfamethoxazole/ cotrimoxazole | ||
| Henna (cosmetic use)35-37 |
| Definite risk of AHA . | “Possible” risk of AHA . | Possible association (less likely) . |
|---|---|---|
| Antimalarial drugs | ||
| Dapsone-containing combinations* | Chloroquine | |
| Pamaquine* | Quinidine | |
| Primaquine* | Quinine | |
| Tafenoquine | ||
| Other drugs | ||
| Ciprofloxacin | Aspirin† | Chloramphenicol |
| Glibenclamide‡ | Menadiol sodium phosphate | Dimercaptosuccinic acid |
| Methylthioninium chloride*,§ | Sulfadiazine | Glibenclamide |
| Moxifloxacin | Sulfasalazine | Mepacrine |
| Nalidixic acid | Sulfonylureas | Vitamin K analogs |
| Niridazole | Tolonium chloride|| | |
| Nitrofurantoin*,¶ | ||
| Norfloxacin | ||
| Ofloxacin | ||
| Phenazopyridine# | ||
| Rasburicase and pegloticase34,* | ||
| Sulfamethoxazole/ cotrimoxazole | ||
| Henna (cosmetic use)35-37 |
Modified from Table 4 of Luzzatto et al,38 where sources and additional references are given.
Evidence-based according to Youngster et al.39
Acetylsalicylic acid. Like for all drugs, hemolysis is dose-related. The regimen of 75 to 100 mg per day, widely used for the prophylaxis of cardiovascular events, is safe for G6PD-deficient persons.
Glyburide.
Methylene blue.
Toluidine blue.
Furadantin.
Pyridium.