RHD and RHCE Alleles identified in 884 patients with SCD
| Allele ISBT name . | Allele detail/alias . | Allele, n . | Allele frequency . |
|---|---|---|---|
| RHD alleles | |||
| RHD*01 | — | 920 | 0.5204 |
| RHD Deletion | — | 294 | 0.1663 |
| RHD*10.00 RHD*DAU0 | RHD*1136T | 229 | 0.1295 |
| RHD*08N.01RHD*Pseudo- gene RHD*Ψ | — | 66 | 0.0373 |
| RHD*03N.01 | RHD*DIIIa-CEVS (4-7)-D | 65 | 0.0368 |
| RHD*09.03.01 RHD*DAR3.01 | RHD*602G,667G | 57 | 0.0322 |
| RHD*10.03 RHD*DAU3 | RHD*835A,1136T | 35 | 0.0198 |
| RHD*10.00.01 RHD*DAU0.01 | RHD*1136T,579A | 21 | 0.0119 |
| RHD*04.01 RHD*DIVa | RHD*186T,410T, 455C,1048C | 16 | 0.0090 |
| RHD*10.05 RHD*DAU5 | RHD*667G,697C,1136T | 12 | 0.0068 |
| RHD*03.01 RHD*DIIIa | RHD*186T,410T,455C,602G,667G,819A | 10 | 0.0057 |
| No ISBT designation (proposed as RHD*03.01.02 RHD*DIII.01.02) | RHD*186T,410T,455C,602G,667G* | 7 | 0.0040 |
| RHD*01W.33RHD*weak D type 33 | RHD*520A | 3 | 0.0017 |
| RHD*09.01.02 RHD*DAR1.02 | RHD*602G,667G, 1025C | 3 | 0.0017 |
| No ISBT designation | RHD*841C (GenBank: KU363613.2)† | 3 | 0.0017 |
| RHD*01.01 | RHD*48C | 2 | 0.0011 |
| RHD*01W.66RHD*weak D type 66 | RHD*916A | 2 | 0.0011 |
| RHD*12.01 RHD*DOL1 | RHD*509C,667G | 2 | 0.0011 |
| RHD*49 RHD*DWN | RHD*1053T, 1057T, 1059G, 1060A, 1061A | 2 | 0.0011 |
| RHD* 01W.137RHD*weak D type 137 | RHD*780A | 1 | 0.0006 |
| RHD*01N.07 | RHD*D-CE (4-7)-D | 1 | 0.0006 |
| RHD*01N.35 | RHD*330_331delGT | 1 | 0.0006 |
| RHD*01W.1RHD*weak D type 1 | RHD*809G | 1 | 0.0006 |
| RHD*01W.45RHD*weak D type 45 | RHD*1195A | 1 | 0.0006 |
| RHD*03.09 RHD*DIII.09 | RHD*186T, 410T, 455C, 667G | 1 | 0.0006 |
| RHD*05.01 RHD*DV.1 | RHD*667G,697C | 1 | 0.0006 |
| RHD*05.05 RHD*DV.5 | RHD*697A | 1 | 0.0006 |
| RHD*09.02.01 RHD*DAR2.01 | RHD*602G, 557G, 697C, 744T, 957A | 1 | 0.0006 |
| RHD*09.03 RHD*DAR3 | RHD*602G,667G | 1 | 0.0006 |
| RHD*10.00.02 RHD*DAU0.02 | RHD*1136T,150C | 1 | 0.0006 |
| No ISBT designation | RHD*1048C (GenBank: KC311353.1)† | 1 | 0.0006 |
| No ISBT designation | RHD*178C (GenBank: KX352163.1)† | 1 | 0.0006 |
| No ISBT designation | RHD*186T (GenBank: JN635688.1)† | 1 | 0.0006 |
| RHD*35 RHD*DMA | RHD*621C | 1 | 0.0006 |
| RHD*37 RHD*DUC2 | RHD*733C | 1 | 0.0006 |
| No ISBT designation | RHD*602G,733C,744T,1136T‡ | 1 | 0.0006 |
| No ISBT designation | RHD*648C (GenBank: JQ405073.1)† | 1 | 0.0006 |
| No ISBT designation | RHD*674T (GenBank: AF510070.1)† | 1 | 0.0006 |
| RHCE alleles | |||
| RHCE*01.01 RHCE*ce.01 | RHCE*ce48C | 402 | 0.2274 |
| RHCE*01 or RHCE*ce RHCE*c RHCE*e | RHCE*ce | 356 | 0.2014 |
| RHCE*01.20.01 RHCE*ce.20.01 RHCE*ceVS01 | RHCE*ce733G | 245 | 0.1386 |
| RHCE*02 or RHCE*Ce RHCE*C RHCE*e | RHCE*Ce | 207 | 0.1171 |
| RHCE*03 or RHCE*cE RHCE*c RHCE*E | RHCE*cE | 180 | 0.1018 |
| RHCE*01.20.03 RHCE*ce.20.03 RHCE*ceVS03 | RHCE*ceS | 80 | 0.0452 |
| RHCE*01.06.01 RHCE*ce.06.01 | RHCE*ceAG | 72 | 0.0407 |
| RHCE*01.20.02 RHCE*ce.20.02 RHCE*ceVS02 | RHCE*ce48C, 733G | 55 | 0.0311 |
| No ISBT designation (proposed as RHCE*01.01.02 RHCE*ce.01.02 | RHCE*ce48C,105T* | 53 | 0.0300 |
| RHCE*01.20.09 RHCE*ce.20.09 RHCE*ceVS09 | RHCE*ce48C, 733G, 941C | 47 | 0.0266 |
| RHCE*01.02.01 RHCE*ce.02.01 | RHCE*ceTI | 22 | 0.0124 |
| RHCE*01.07.01 RHCE*ce.07.01 | RHCE*ceMO | 20 | 0.0113 |
| RHCE*01.08 RHCE*ce.08 | RHCE*ceBI | 4 | 0.0023 |
| RHCE*01.20.06 RHCE*ce.20.06 RHCE*ceVS06 | RHCE*ceCF | 4 | 0.0023 |
| RHCE*01.05.01 RHCE*ce.05.01 | RHCE*ceEK | 3 | 0.0017 |
| RHCE*01.20.05 RHCE*ce.20.05 RHCE*ceVS05 | RHCE*ce733G, 1006T | 3 | 0.0017 |
| RHCE*03.04 RHCE*cE.04 | RHCE*cEIV | 3 | 0.0017 |
| RHCE*04 RHCE*CE | RHCE*CE | 2 | 0.0011 |
| RHCE*01.03 RHCE*ce.03 | RHCE*ce1025T | 1 | 0.0006 |
| RHCE*01.04.01 RHCE*ce.04.01 | RHCE*ceAR | 1 | 0.0006 |
| RHCE*01.06.02 RHCE*ce.06.02 | RHDE*ceAG.0 2 | 1 | 0.0006 |
| RHCE*01.06.05 RHCE*ce.06.05 | RHCE*ceAG.0 5 | 1 | 0.0006 |
| RHCE*01.20.04.02 RHCE*ce.20.04.02 RHCE*ceVS04.02 | RHCE*ceTI type 2-like | 1 | 0.0006 |
| RHCE*01.20.07 RHCE*ce.20.07 RHCE*ceVS07 | RHCE*ceJAL | 1 | 0.0006 |
| RHCE*02.08.01 RHCE*Ce.08.01 | RHCE*CeCW | 1 | 0.0006 |
| RHCE*02.22 RHCE*Ce.22 | RHCE*Ce667T | 1 | 0.0006 |
| RHCE*02.30 RHCE*Ce.30 | RHCE*Ce733G | 1 | 0.0006 |
| RHCE*03.18 RHCE*cE.18 | RHCE*cE48C | 1 | 0.0006 |
| Allele ISBT name . | Allele detail/alias . | Allele, n . | Allele frequency . |
|---|---|---|---|
| RHD alleles | |||
| RHD*01 | — | 920 | 0.5204 |
| RHD Deletion | — | 294 | 0.1663 |
| RHD*10.00 RHD*DAU0 | RHD*1136T | 229 | 0.1295 |
| RHD*08N.01RHD*Pseudo- gene RHD*Ψ | — | 66 | 0.0373 |
| RHD*03N.01 | RHD*DIIIa-CEVS (4-7)-D | 65 | 0.0368 |
| RHD*09.03.01 RHD*DAR3.01 | RHD*602G,667G | 57 | 0.0322 |
| RHD*10.03 RHD*DAU3 | RHD*835A,1136T | 35 | 0.0198 |
| RHD*10.00.01 RHD*DAU0.01 | RHD*1136T,579A | 21 | 0.0119 |
| RHD*04.01 RHD*DIVa | RHD*186T,410T, 455C,1048C | 16 | 0.0090 |
| RHD*10.05 RHD*DAU5 | RHD*667G,697C,1136T | 12 | 0.0068 |
| RHD*03.01 RHD*DIIIa | RHD*186T,410T,455C,602G,667G,819A | 10 | 0.0057 |
| No ISBT designation (proposed as RHD*03.01.02 RHD*DIII.01.02) | RHD*186T,410T,455C,602G,667G* | 7 | 0.0040 |
| RHD*01W.33RHD*weak D type 33 | RHD*520A | 3 | 0.0017 |
| RHD*09.01.02 RHD*DAR1.02 | RHD*602G,667G, 1025C | 3 | 0.0017 |
| No ISBT designation | RHD*841C (GenBank: KU363613.2)† | 3 | 0.0017 |
| RHD*01.01 | RHD*48C | 2 | 0.0011 |
| RHD*01W.66RHD*weak D type 66 | RHD*916A | 2 | 0.0011 |
| RHD*12.01 RHD*DOL1 | RHD*509C,667G | 2 | 0.0011 |
| RHD*49 RHD*DWN | RHD*1053T, 1057T, 1059G, 1060A, 1061A | 2 | 0.0011 |
| RHD* 01W.137RHD*weak D type 137 | RHD*780A | 1 | 0.0006 |
| RHD*01N.07 | RHD*D-CE (4-7)-D | 1 | 0.0006 |
| RHD*01N.35 | RHD*330_331delGT | 1 | 0.0006 |
| RHD*01W.1RHD*weak D type 1 | RHD*809G | 1 | 0.0006 |
| RHD*01W.45RHD*weak D type 45 | RHD*1195A | 1 | 0.0006 |
| RHD*03.09 RHD*DIII.09 | RHD*186T, 410T, 455C, 667G | 1 | 0.0006 |
| RHD*05.01 RHD*DV.1 | RHD*667G,697C | 1 | 0.0006 |
| RHD*05.05 RHD*DV.5 | RHD*697A | 1 | 0.0006 |
| RHD*09.02.01 RHD*DAR2.01 | RHD*602G, 557G, 697C, 744T, 957A | 1 | 0.0006 |
| RHD*09.03 RHD*DAR3 | RHD*602G,667G | 1 | 0.0006 |
| RHD*10.00.02 RHD*DAU0.02 | RHD*1136T,150C | 1 | 0.0006 |
| No ISBT designation | RHD*1048C (GenBank: KC311353.1)† | 1 | 0.0006 |
| No ISBT designation | RHD*178C (GenBank: KX352163.1)† | 1 | 0.0006 |
| No ISBT designation | RHD*186T (GenBank: JN635688.1)† | 1 | 0.0006 |
| RHD*35 RHD*DMA | RHD*621C | 1 | 0.0006 |
| RHD*37 RHD*DUC2 | RHD*733C | 1 | 0.0006 |
| No ISBT designation | RHD*602G,733C,744T,1136T‡ | 1 | 0.0006 |
| No ISBT designation | RHD*648C (GenBank: JQ405073.1)† | 1 | 0.0006 |
| No ISBT designation | RHD*674T (GenBank: AF510070.1)† | 1 | 0.0006 |
| RHCE alleles | |||
| RHCE*01.01 RHCE*ce.01 | RHCE*ce48C | 402 | 0.2274 |
| RHCE*01 or RHCE*ce RHCE*c RHCE*e | RHCE*ce | 356 | 0.2014 |
| RHCE*01.20.01 RHCE*ce.20.01 RHCE*ceVS01 | RHCE*ce733G | 245 | 0.1386 |
| RHCE*02 or RHCE*Ce RHCE*C RHCE*e | RHCE*Ce | 207 | 0.1171 |
| RHCE*03 or RHCE*cE RHCE*c RHCE*E | RHCE*cE | 180 | 0.1018 |
| RHCE*01.20.03 RHCE*ce.20.03 RHCE*ceVS03 | RHCE*ceS | 80 | 0.0452 |
| RHCE*01.06.01 RHCE*ce.06.01 | RHCE*ceAG | 72 | 0.0407 |
| RHCE*01.20.02 RHCE*ce.20.02 RHCE*ceVS02 | RHCE*ce48C, 733G | 55 | 0.0311 |
| No ISBT designation (proposed as RHCE*01.01.02 RHCE*ce.01.02 | RHCE*ce48C,105T* | 53 | 0.0300 |
| RHCE*01.20.09 RHCE*ce.20.09 RHCE*ceVS09 | RHCE*ce48C, 733G, 941C | 47 | 0.0266 |
| RHCE*01.02.01 RHCE*ce.02.01 | RHCE*ceTI | 22 | 0.0124 |
| RHCE*01.07.01 RHCE*ce.07.01 | RHCE*ceMO | 20 | 0.0113 |
| RHCE*01.08 RHCE*ce.08 | RHCE*ceBI | 4 | 0.0023 |
| RHCE*01.20.06 RHCE*ce.20.06 RHCE*ceVS06 | RHCE*ceCF | 4 | 0.0023 |
| RHCE*01.05.01 RHCE*ce.05.01 | RHCE*ceEK | 3 | 0.0017 |
| RHCE*01.20.05 RHCE*ce.20.05 RHCE*ceVS05 | RHCE*ce733G, 1006T | 3 | 0.0017 |
| RHCE*03.04 RHCE*cE.04 | RHCE*cEIV | 3 | 0.0017 |
| RHCE*04 RHCE*CE | RHCE*CE | 2 | 0.0011 |
| RHCE*01.03 RHCE*ce.03 | RHCE*ce1025T | 1 | 0.0006 |
| RHCE*01.04.01 RHCE*ce.04.01 | RHCE*ceAR | 1 | 0.0006 |
| RHCE*01.06.02 RHCE*ce.06.02 | RHDE*ceAG.0 2 | 1 | 0.0006 |
| RHCE*01.06.05 RHCE*ce.06.05 | RHCE*ceAG.0 5 | 1 | 0.0006 |
| RHCE*01.20.04.02 RHCE*ce.20.04.02 RHCE*ceVS04.02 | RHCE*ceTI type 2-like | 1 | 0.0006 |
| RHCE*01.20.07 RHCE*ce.20.07 RHCE*ceVS07 | RHCE*ceJAL | 1 | 0.0006 |
| RHCE*02.08.01 RHCE*Ce.08.01 | RHCE*CeCW | 1 | 0.0006 |
| RHCE*02.22 RHCE*Ce.22 | RHCE*Ce667T | 1 | 0.0006 |
| RHCE*02.30 RHCE*Ce.30 | RHCE*Ce733G | 1 | 0.0006 |
| RHCE*03.18 RHCE*cE.18 | RHCE*cE48C | 1 | 0.0006 |
Alleles that are not considered by ISBT because of identical phenotype changes to alleles included in ISBT. RHD*186T,410T,455C,602G,667G has the same amino acid changes as RHD*03.01 RHD*DIIIa (RHD*186T,410T,455C,602G,667G,819A), with c. 819G>A being silent; RHCE*ce48C,105T has the same amino-acid changes as RHCE*48C, with c. 105C>T being silent. Proposed designations in line with the anticipated ISBT nomenclature for the 2 alleles are included in parentheses.
Alleles that are not included by ISBT but have been reported to GenBank. GenBank IDs are listed.
Novel RHD allele.