CH characteristics increasing risk for leukemia transformation
| Definition . | References . |
|---|---|
| Total no. of mutations | |
| >1 gene | 10,13,16,17 |
| >250 somatic SNPs | 4 |
| VAF | |
| >10% | 3,17 |
| RDW | |
| >14% | 13,16 |
| Specific gene | |
| Study specific: | 13,16,17 |
| TP53, U2AF1/spliceosome | |
| IDH1/2, RUNX1, PHF6 | 17 |
| Specific variant | 18 |
| DNMT3A (R882C/H, R729W, R326C, R320*, R736H/C, Y735C, W860R, R771*, R598*, P904L) | |
| SRSF2 P95R/H/L | |
| SF3B1 K700E, K666N | |
| JAK2 V617F | |
| IDH2 R140Q | |
| GNB1 K57E |
| Definition . | References . |
|---|---|
| Total no. of mutations | |
| >1 gene | 10,13,16,17 |
| >250 somatic SNPs | 4 |
| VAF | |
| >10% | 3,17 |
| RDW | |
| >14% | 13,16 |
| Specific gene | |
| Study specific: | 13,16,17 |
| TP53, U2AF1/spliceosome | |
| IDH1/2, RUNX1, PHF6 | 17 |
| Specific variant | 18 |
| DNMT3A (R882C/H, R729W, R326C, R320*, R736H/C, Y735C, W860R, R771*, R598*, P904L) | |
| SRSF2 P95R/H/L | |
| SF3B1 K700E, K666N | |
| JAK2 V617F | |
| IDH2 R140Q | |
| GNB1 K57E |
RDW, red cell distribution width.