Demographic and clinical characteristics by inhibitor status among 6624 persons with NSHA in the United States, 2010-2018
| Characteristics . | Noninhibitor (n = 6453)* . | Inhibitor (n = 171)* . | P . |
|---|---|---|---|
| Year of birth | 1994 (1974-2004) | 1991 (1971-2000) | |
| Age, y | |||
| At start of observation period | 19 (8-39) | 21 (11-41) | |
| At end of follow-up or death | 25 (14-44) | 27 (18-47) | |
| Sex | |||
| Female | 927 (14.4) | 1 (0.6) | <.001 |
| Male | 5524 (85.6) | 170 (99.4) | |
| Race | |||
| White | 5367 (83.2) | 132 (77.2) | <.001 |
| Black | 512 (7.9) | 31 (18.1) | |
| Other/unknown | 574 (8.9) | 8 (4.7) | |
| Ethnicity | |||
| Hispanic | 1182 (18.3) | 17 (9.9) | .013 |
| Non-Hispanic | 5192 (80.5) | 153 (89.5) | |
| Unknown | 79 (1.2) | 1 (0.6) | |
| Severity | |||
| Mild | 4640 (71.9) | 80 (46.8) | <.001 |
| Moderate | 1813 (28.1) | 91 (53.2) | |
| FVIII exposure | |||
| Yes | 4957 (76.8) | 165 (96.5) | <.001 |
| No | 551 (8.5) | 4 (2.3) | |
| Unknown | 945 (14.3) | 2 (1.2) | |
| Infections | |||
| Hepatitis B | 102 (1.6) | 3 (1.8) | NS |
| Hepatitis C | 596 (9.2) | 27 (15.8) | .004 |
| HIV | 166 (2.6) | 4 (2.3) | NS |
| Characteristics . | Noninhibitor (n = 6453)* . | Inhibitor (n = 171)* . | P . |
|---|---|---|---|
| Year of birth | 1994 (1974-2004) | 1991 (1971-2000) | |
| Age, y | |||
| At start of observation period | 19 (8-39) | 21 (11-41) | |
| At end of follow-up or death | 25 (14-44) | 27 (18-47) | |
| Sex | |||
| Female | 927 (14.4) | 1 (0.6) | <.001 |
| Male | 5524 (85.6) | 170 (99.4) | |
| Race | |||
| White | 5367 (83.2) | 132 (77.2) | <.001 |
| Black | 512 (7.9) | 31 (18.1) | |
| Other/unknown | 574 (8.9) | 8 (4.7) | |
| Ethnicity | |||
| Hispanic | 1182 (18.3) | 17 (9.9) | .013 |
| Non-Hispanic | 5192 (80.5) | 153 (89.5) | |
| Unknown | 79 (1.2) | 1 (0.6) | |
| Severity | |||
| Mild | 4640 (71.9) | 80 (46.8) | <.001 |
| Moderate | 1813 (28.1) | 91 (53.2) | |
| FVIII exposure | |||
| Yes | 4957 (76.8) | 165 (96.5) | <.001 |
| No | 551 (8.5) | 4 (2.3) | |
| Unknown | 945 (14.3) | 2 (1.2) | |
| Infections | |||
| Hepatitis B | 102 (1.6) | 3 (1.8) | NS |
| Hepatitis C | 596 (9.2) | 27 (15.8) | .004 |
| HIV | 166 (2.6) | 4 (2.3) | NS |
NS, not significant.
Data presented are medians (interquartile range) or numbers (percentages). Categorical variables were analyzed with χ2 test or Fisher’s exact test, as appropriate.