Treatment summary of all bleeding episodes
| . | No. bleeding episodes . | Total no. infusions . | Median (range) no. infusions/bleed . | Median (range) VWF:RCo dose (IU/kg) . | Median (range) rFVIII dose (IU/kg) . | % bleeds (N = 192) rated* excellent or good (n excellent/good) . |
|---|---|---|---|---|---|---|
| Subject VWF type | ||||||
| Type 3 | 175 | 219 | 1 (1-4) | 48.2 (23.8-184.9) | 33.6 (16.6-129.3) | 100% (171/4) |
| Type 2A | 16 | 18 | 1 (1-2) | 50.2 (32.9-90.2) | 32.5 (23.7-38.6) | 100% (14/2) |
| Type 2N | 1 | 1 | 1 (1-1) | 54.3 (54.3-54.3) | NA† | 100% (1/0) |
| Bleed severity | ||||||
| Minor | 122 | 132 | 1 (1-3) | 43.3 (25.2-158.2) | 33.5 (17.6-86.2) | 100% (119/3) |
| Moderate | 61 | 89 | 1 (1-4) | 52.7 (23.8-184.9) | 36.9 (16.6-129.3) | 100% (59/2) |
| Major/severe | 7 | 15 | 2 (1-3) | 100.0 (57.5-135.0) | 39.0 (25.0-42.3) | 100% (6/1) |
| Unknown | 2 | 2 | 1 (1-1) | 33.4 (33.1-33.8) | 23.3 (23.1-23.6) | 100% (2/0) |
| Bleed site‡ | ||||||
| Joint | 59 | 66 | 1 (1-3) | 48.2 (23.8-139.6) | 34.9 (16.6-129.3) | 100% (57/2) |
| Gastrointestinal | 6 | 10 | 1 (1-2) | 60.0 (53.6-121.1) | 33.2 (19.3-49.4) | 100% (5/1) |
| Mucosal | 106 | 121 | 1 (1-4) | 43.3 (23.8-184.9) | 30.6 (16.6-61.3) | 100% (103/3) |
| Other§ | 37 | 57 | 1 (1-4) | 52.2 (25.2-184.9) | 36.8 (17.6-86.2) | 100% (36/1) |
| Bleed cause | ||||||
| Spontaneous | 165 | 255 | 1 (1-4) | 46.5 (23.8-184.9) | 33.6 (16.6-86.2) | 100% (160/5) |
| Traumatic | 26 | 30 | 1 (1-3) | 51.9 (25.2-139.6) | 35.8 (17.6-129.3) | 100% (26/0) |
| Unknown | 1 | 3 | 3 (3-3) | 125.5 (125.5-125.5) | 50.3 (50.3-50.3) | 100% (0/1) |
| . | No. bleeding episodes . | Total no. infusions . | Median (range) no. infusions/bleed . | Median (range) VWF:RCo dose (IU/kg) . | Median (range) rFVIII dose (IU/kg) . | % bleeds (N = 192) rated* excellent or good (n excellent/good) . |
|---|---|---|---|---|---|---|
| Subject VWF type | ||||||
| Type 3 | 175 | 219 | 1 (1-4) | 48.2 (23.8-184.9) | 33.6 (16.6-129.3) | 100% (171/4) |
| Type 2A | 16 | 18 | 1 (1-2) | 50.2 (32.9-90.2) | 32.5 (23.7-38.6) | 100% (14/2) |
| Type 2N | 1 | 1 | 1 (1-1) | 54.3 (54.3-54.3) | NA† | 100% (1/0) |
| Bleed severity | ||||||
| Minor | 122 | 132 | 1 (1-3) | 43.3 (25.2-158.2) | 33.5 (17.6-86.2) | 100% (119/3) |
| Moderate | 61 | 89 | 1 (1-4) | 52.7 (23.8-184.9) | 36.9 (16.6-129.3) | 100% (59/2) |
| Major/severe | 7 | 15 | 2 (1-3) | 100.0 (57.5-135.0) | 39.0 (25.0-42.3) | 100% (6/1) |
| Unknown | 2 | 2 | 1 (1-1) | 33.4 (33.1-33.8) | 23.3 (23.1-23.6) | 100% (2/0) |
| Bleed site‡ | ||||||
| Joint | 59 | 66 | 1 (1-3) | 48.2 (23.8-139.6) | 34.9 (16.6-129.3) | 100% (57/2) |
| Gastrointestinal | 6 | 10 | 1 (1-2) | 60.0 (53.6-121.1) | 33.2 (19.3-49.4) | 100% (5/1) |
| Mucosal | 106 | 121 | 1 (1-4) | 43.3 (23.8-184.9) | 30.6 (16.6-61.3) | 100% (103/3) |
| Other§ | 37 | 57 | 1 (1-4) | 52.2 (25.2-184.9) | 36.8 (17.6-86.2) | 100% (36/1) |
| Bleed cause | ||||||
| Spontaneous | 165 | 255 | 1 (1-4) | 46.5 (23.8-184.9) | 33.6 (16.6-86.2) | 100% (160/5) |
| Traumatic | 26 | 30 | 1 (1-3) | 51.9 (25.2-139.6) | 35.8 (17.6-129.3) | 100% (26/0) |
| Unknown | 1 | 3 | 3 (3-3) | 125.5 (125.5-125.5) | 50.3 (50.3-50.3) | 100% (0/1) |