Table 1. Associated SNPs at chromosome 2... | American Society of Hematology

Table 1.

Associated SNPs at chromosome 2 and 5 loci

Chromosome*	Position*	SNP rs ID		Minor allele	Major allele	MAF cases	MAF controls	P	Odds ratio (95% CI)	Global MAF	YRI MAF	CEU MAF
2	15 252,558	rs66516066	Imputed	T	A	0.06	0.23	2.01e-08*	0.21 (0.11-0.37)	0.07	0.11	0.08
2	15 234,153	rs56737264	Genotyped	G	A	0.09	0.27	1.56e-07	0.28 (0.17-0.46)	0.07	0.15	0.07
2	15 242,283	rs67088901	Genotyped	A	G	0.08	0.23	6.36e-07	0.28 (0.16-0.47)	0.07	0.13	0.08
5	159 277,285	rs75853687	Genotyped	A	G	0.12	0.01	8.36e-08	16.46 (3.91-69.26)	0.02	0.10	—
5	159 285,569	rs116416070	Imputed	T	C	0.11	0.00	1.13e-07	28.76 (3.89-212.8)	0.01	0.10	—
5	159 285,922	rs114221476	Imputed	A	G	0.11	0.00	1.13e-07	28.76 (3.89-212.8)	0.01	0.10	—

Chromosome*	Position*	SNP rs ID		Minor allele	Major allele	MAF cases	MAF controls	P	Odds ratio (95% CI)	Global MAF	YRI MAF	CEU MAF
2	15 252,558	rs66516066	Imputed	T	A	0.06	0.23	2.01e-08*	0.21 (0.11-0.37)	0.07	0.11	0.08
2	15 234,153	rs56737264	Genotyped	G	A	0.09	0.27	1.56e-07	0.28 (0.17-0.46)	0.07	0.15	0.07
2	15 242,283	rs67088901	Genotyped	A	G	0.08	0.23	6.36e-07	0.28 (0.16-0.47)	0.07	0.13	0.08
5	159 277,285	rs75853687	Genotyped	A	G	0.12	0.01	8.36e-08	16.46 (3.91-69.26)	0.02	0.10	—
5	159 285,569	rs116416070	Imputed	T	C	0.11	0.00	1.13e-07	28.76 (3.89-212.8)	0.01	0.10	—
5	159 285,922	rs114221476	Imputed	A	G	0.11	0.00	1.13e-07	28.76 (3.89-212.8)	0.01	0.10	—

SNP rs66516066 on chromosome 2 surpasses genome wide significance. Chromosome 5 SNPs are not observed in CEU cohort of 1000 genomes. Italics differentiate genotyped from imputed (inferred) variants.

All positions are relative to GRCh37/hg19 human genome build.

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