Elevated plasma levels of Sdc-1, sTM, or both are associated with mortality. Plasma levels of Sdc-1 (A), but not sTM (B), are higher in patients who died than in those who survived. Kaplan-Meier survival analyses in patients with Sdc-1 <3.3 ng/mL vs Sdc-1 ≥3.3 ng/mL (C) or sTM <4.0 ng/mL vs ≥4.0 ng/mL (D) or with a double increase in Sdc-1 (≥3.3 ng/mL) and sTM (≥4.0 ng/mL) vs a single change in either Sdc-1 or sTM in the same direction or the opposite direction (E). A Mantel-Cox test was performed to determine statistical significance. Values of P < .05 and P < .01 are considered to be statistically significant and highly significant, respectively. ****P < .0001.