Figure 1.
LCMV induces hyperinflammation in Il18tg mice. The indicated genotypes were infected with 200 000 pfu of LCMV Armstrong and assessed for (A) survival and (B) weight (statistical significance for WT vs Il18tg comparison), (C) hemoglobin, platelet count, and serum AST, and (D) serum IFNg and IL-18. (E) Representative splenic touch preparation from Il18tg mouse on day 8 (Wright-Geimsa). Data are composites of at least 3 independent experiments with a minimum of 3 mice per genotype, apart from AST, which is a composite of 2 experiments. Daily cytokine measurements in panel D represent a minimum of 4 mice per genotype. *Adjusted P < .05, **P < .01, ***P < .001, ***P < .0001 by 1-way analysis of variance (ANOVA) with Tukey post-test on day 8 values. Significance is only shown for comparisons where adjusted P < .05. Error bars represent standard error of the mean (SEM).

LCMV induces hyperinflammation in Il18tg mice. The indicated genotypes were infected with 200 000 pfu of LCMV Armstrong and assessed for (A) survival and (B) weight (statistical significance for WT vs Il18tg comparison), (C) hemoglobin, platelet count, and serum AST, and (D) serum IFNg and IL-18. (E) Representative splenic touch preparation from Il18tg mouse on day 8 (Wright-Geimsa). Data are composites of at least 3 independent experiments with a minimum of 3 mice per genotype, apart from AST, which is a composite of 2 experiments. Daily cytokine measurements in panel D represent a minimum of 4 mice per genotype. *Adjusted P < .05, **P < .01, ***P < .001, ***P < .0001 by 1-way analysis of variance (ANOVA) with Tukey post-test on day 8 values. Significance is only shown for comparisons where adjusted P < .05. Error bars represent standard error of the mean (SEM).

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