Virus-induced hyperinflammation in Il18tg mice is largely rescued by CD8 T-cell depletion. Mice of the indicated genotypes were treated with CD8-depleting (clone YTS169) or control antibody, infected with LCMV-Arm, and assessed at day 8 for weight loss, spleen weight, hemoglobin (Hb), serum AST, serum TNFα, IFNg, and IL-18. Horizontal dashed lines indicate the median value of uninfected WT control mice. Results are composites of at least 2 independent experiments with a minimum of 3 mice per group.*Adjusted P < .05, **P < .01, ***P < .001, ***P < .0001 by 1-way ANOVA with Tukey post-test on day 8 values. Significance is only shown for comparisons where adjusted P < .05. Error bars represent SEM.