Virus-induced hyperinflammation in Il18tg mice is not associated with immunodeficiency or prolonged antigen presentation. After LCMV-Arm infection, mice of the indicated genotypes were assessed for (A) the presence of LCMV RNA in the spleen by qPCR. (B) In vivo killing assay: WT splenocytes loaded with GP33 peptide were labeled with TagIT Violet, and control WT splenocytes were labeled with CFSE. Equal proportions of both were then adoptively transferred into mice of the indicated genotypes on day 8 of LCMV-Arm infection and remaining cells were assessed 24 hours later in recipient spleens. (C) Equal numbers of CFSE-labeled P14 CD8 T cells were transferred into mice of the indicated genotypes on day 7 of infection. Spleens were assessed 72 hours later for the persistence/proliferation of transferred cells. Boxes indicate CFSE fluorescence of undivided cells. # indicates non-CFSE labeled host GP33 tetramer + CD8 T cells.