Figure 1.
Summary of known fusions detected in 572 AML and 630 MDS patients. The plot was generated by Circos. The width of the connecting arcs reflects the recurrence of the fusion gene with the arrows indicating the transcription orientation from 5′ fusion gene partner to 3′ fusion gene partner. Gray arcs represent canonical fusions (in AML) associated with the entity-defining translocations RUNX1-RUNX1T1, PML-RARA, CBFB-MYH11, KMT2A-MLLT3, and DEK-NUP214, light blue arcs represent other previously reported fusion genes in AML and MDS. The outermost circle indicates the chromosomal location of the unique fusion genes. The inner circle depicts the validation methods of the detected fusion genes. Dark gray, validated by WGS; light gray, validated by CBA/FISH.

Summary of known fusions detected in 572 AML and 630 MDS patients. The plot was generated by Circos. The width of the connecting arcs reflects the recurrence of the fusion gene with the arrows indicating the transcription orientation from 5′ fusion gene partner to 3′ fusion gene partner. Gray arcs represent canonical fusions (in AML) associated with the entity-defining translocations RUNX1-RUNX1T1, PML-RARA, CBFB-MYH11, KMT2A-MLLT3, and DEK-NUP214, light blue arcs represent other previously reported fusion genes in AML and MDS. The outermost circle indicates the chromosomal location of the unique fusion genes. The inner circle depicts the validation methods of the detected fusion genes. Dark gray, validated by WGS; light gray, validated by CBA/FISH.

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