Stucture of wild-type NUP98 and NUP98 fusions. (A) Structure of wild-type NUP98. (B) Structure of NUP98 fusions, including relevant functional domains and malignancies reported for each partner gene. The longest fusion gene is shown along with alternate breakpoints. Arrows denote breakpoints, and asterisk (*) denotes fusion partners for which multiple isoforms have been identified. CMML, chronic myelomonocytic leukemia; HMG, high-mobility group; IQ, isoleucine glutamine; JMML, juvenile myelomonocytic leukemia; MYST, MOZ, Ybf2, Sas2, and TIP60; PHD, plant homeodomain; SET, Su(var)3-9, enhancer-of-zeste and trithorax.