M-CSF but not GM-CSF human macrophages upregulate genes involved in growth and angiogenesis after the addition of exogenous Ado and PGE₂. Donor matched human monocytes were cultured in M-CSF (light blue bars) and GM-CSF (red bars) for 7 days and then were left unstimulated or were stimulated with LPS, LPS + Ado, or LPS + PGE₂ for 4 hours before mRNA was isolated and analyzed by real-time quantitative polymerase chain reaction (n = 5). *P ≤ .05; **P ≤ .01; ***P ≤ .001; ****P ≤ .0001.