Morphologic profiles. (A) Consensus clustering applied to the discovery cohort reveals 5 morphologic profiles. (B) Distributions of each morphologic feature among the 5 morphologic profiles (P). Color is used to describe the prevalence of individual traits within each of the 5 profiles, with red depicting high and blue depicting low prevalence, respectively. (C) Kaplan-Meier curves for overall survival among patients identified by the 5 morphologic profiles. Survival differs significantly among the 5 profiles when evaluated using the log-rank test (*P < .05), demonstrating that the morphologic profiles confer prognostic utility. A, anemia; E, erythoroid dysplasia; Emg, elevated megakaryocytes; F, fibrosis; M, myeloid dysplasia; Mef, myelofibrosis; MgK, megakaryocytic dysplasia; Mnc, monocytosis; N, neutropenia; P, morphologic profiles; Th, thrombocytopenia.