Association between ASNS methylation and chromosomal abnormalities in BCP-ALL samples. (A-B) Association between ASNS methylation and karyotypes in BCP-ALL cases of the NOPHO cohort. P values in (A) a Mann-Whitney U test or (B) χ² test are indicated. (C-D) Association of ASNS methylation with representative chromosomal abnormalities in BCP-ALL cases of the (C) NOPHO cohort and (D) 3 cohorts. (E) Association of triple trisomies with ASNS methylation in NOPHO (left panel) and CCCS (right panel) cohorts. P values in a Mann-Whitney U test are indicated.