Figure 6.
Runx1 is required for Cbfb-MYH11–induced generation of functional AMP population. Uniform manifold approximation and projection plots of AMP single cells from Mx1-CreCbfb+/56M and Runx1f/fMx1-CreCbfb+/56M mice at 2 to 3 weeks after pIpC treatment. (A-C) the first set of experiments. (D-F) The second set of repeat experiments. (A,D) Clusters based on gene expression patterns. (B,E) Distributions of the cells of the 2 genotypes among the clusters. (C,F) Feature plot depicting the expression of genes (Car1 and C1QTNF12) across different cell populations (red, high; gray, low).

Runx1 is required for Cbfb-MYH11–induced generation of functional AMP population. Uniform manifold approximation and projection plots of AMP single cells from Mx1-CreCbfb+/56M and Runx1f/fMx1-CreCbfb+/56M mice at 2 to 3 weeks after pIpC treatment. (A-C) the first set of experiments. (D-F) The second set of repeat experiments. (A,D) Clusters based on gene expression patterns. (B,E) Distributions of the cells of the 2 genotypes among the clusters. (C,F) Feature plot depicting the expression of genes (Car1 and C1QTNF12) across different cell populations (red, high; gray, low).

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