Downregulated genes after combined menin-MLL and FLT3 inhibition are enriched for STAT5A target genes. (A) Gene set enrichment analysis of gene expression changes in MV411 cells treated with combined MI-503 (2.5 µM; 3 days) and quizartinib (3 nM; 24 hours) compared with STAT5A targets. (B) Heatmap of differentially expressed genes (log2 change >1 and < −1, and adjusted P < .05) in MV411 cells after single and combined treatment with MI-503 (2.5 µM, 3 days) and quizartinib (3 nM, 24 hours). Target genes of STAT5A are indicated.