Classification of post-PV/ET AML according to their mutational landscape. Heat map based on the Euclidean distance, displaying the VAF of additional mutations. Genes are listed on the x-axis, and each row corresponds to a patient. The color scale represents the scaled abundance of each variable and is proportional to the allele burden (darker red represents higher allele burden). Three groups were identified for short-term (blue), long-term (orange), and intermediate (green) transformation.