IMiD pretreatment restored AMG 701–induced MM cell lysis in the presence of BMSCs and OCs. T cells were pretreated with len (1 μM), pom (1 μM), or control medium (C) for 4 days. AMG 701–induced TDCC against H929 MM cell lysis was measured in the presence (+) or absence of BMSCs or OCs derived from RRMM patients (n = 3) (E:T = 5:1). The percentage of MM cell lysis (means ± SDs) was evaluated at 1-day coculture. Three independent experiments were done with triplicates for each condition. All results are shown as means ± SDs. *P < .05; **P < .01; ***P < .001.