Potency, toxicity and sequencing of different forms of immunotherapy. (A) Comparison of immunotherapy treatment modalities. (B) Potential therapeutic sequence for newly diagnosed MM: debulking with anti-CD38 Ab-based regimen and consolidation and induction of MRD⁻ status with T-cell–redirecting therapy, such as CAR T-cell therapy, followed by maintenance. Gray cells indicate MM cells; light cells indicate T cells.