Genomic profile of somatic mutations, copy number variants (CNVs), and LOH in all samples during idasanutlin therapy. The columns (n = 14) indicate samples for each patient, from baseline to the last evaluable time point in the therapy (4-33 months), sorted according to the patient’s number and his or her timeline samples (eg, patient_1 baseline, C7D1, cycle 19 day 1 [C19D1]). Each row in the top panel (“Substitutions/Indels”) represents a gene that is mutated (n = 10). In the middle panel, each row represents the results of cytogenetic analysis of each related samples. Samples that had no cytogenetic analysis are highlighted by gray color (N_E). The bottom panel indicates CNAC-detected aberration (all LOH) events. The upper bar plot indicates the number of somatic mutation(s) per sample, colored according to the type of the detected mutation, as denoted in the legend. The right bar plot shows the number of somatic mutations per gene or copy number and LOH event. The frequency of mutations in the entire cohort (14 samples) is listed on the left border of the figure. cnLOH, copy number neutral LOH.