Figure 4.
Cofactor-induced vs substrate-induced changes in deuterium uptake. (A) Among the changes induced by the EGRck alone, the 220-loopCT appears to be the only region involved on the protease domain together with the hinge EGF-1/EGF-2 on the light chain (pink). (B) FVIIIa induces changes on EGF-2, helix 126-132CT, helix 236-240CT, and the C-terminal part of 162-helixCT (blue). Data indicate the cluster of helices, helix 126-132CT, helix 236-240CT, and the C-terminal part of 162-helixCT, known as exosite II, as the putative FVIIIa binding site.

Cofactor-induced vs substrate-induced changes in deuterium uptake. (A) Among the changes induced by the EGRck alone, the 220-loopCT appears to be the only region involved on the protease domain together with the hinge EGF-1/EGF-2 on the light chain (pink). (B) FVIIIa induces changes on EGF-2, helix 126-132CT, helix 236-240CT, and the C-terminal part of 162-helixCT (blue). Data indicate the cluster of helices, helix 126-132CT, helix 236-240CT, and the C-terminal part of 162-helixCT, known as exosite II, as the putative FVIIIa binding site.

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