Schematic representation of the interactions across the PLAU locus in nonaffected individuals (normal, top) and in individuals affected by Quebec platelet disorder (QPD, bottom). The different genomic compartments are represented by the pink (sub-TAD_PLAU) and green box (sub-TAD_VCL ). The duplicated segments are represented in blue and orange. TAD, topologically associating domain. See Figure 6 in the article by Liang et al that begins on page 2679.